ACSS1 Antibody (YA4526)
(Synonyms: ACAS2L; ACECS1; AceCS2L)ACSS1 Antibody (YA4526) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ACSS1.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
ACSS1 Antibody (YA4526) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ACSS1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 75 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 75 kDa
Purified recombinant fragment of human ACSS1 (AA: 548-689) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ACSS1 catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate. Can also utilize propionate with a much lower affinity. Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions. Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient[1].
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Subcellular Localization
Mitochondrion matrix
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Isoforms & Post-Translational Modification
Q9NUB1 has 4 isomers: Q9NUB1-1: 74857 Da (predicted); Q9NUB1-2: 74627 Da (predicted); Q9NUB1-3: 62722 Da (predicted); Q9NUB1-4: 62688 Da (predicted).
Reversibly acetylated on Lys-642 (PubMed:16788062). The acetyl-CoA synthase activity is inhibited by acetylation and activated by deacetylation mediated by the deacetylase SIRT3 -
Subunit
Interacts with SIRT3
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SwissProt ID
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Synonyms
ACAS2L; ACECS1; AceCS2L
Documentation
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