MICAL2 - microtubule associated monooxygenase, calponin and LIM domain containing 2 Gene

Also Known as MICAL-2; MICALCL; Ebitein1; mical-cL; MICAL2PV1; MICAL2PV2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9645

About MICAL2

Cytogenetic location: 11p15.3 Genomic coordinates (GRCh38): 11:12,110,590-12,362,140 (from NCBI)

This gene has 37 transcripts (splice variants), 292 orthologues and 36 paralogues. Broad expression in testis (RPKM 23.1), colon (RPKM 17.9) and 24 other tissues.

Summary

The protein encoded by this gene is a monooxygenase that enhances depolymerization of F-actin and is therefore involved in cytoskeletal dynamics. The encoded protein is a regulator of the SRF signaling pathway. Increased expression of this gene has been associated with Cancer progression and metastasis. [provided by RefSeq, Oct 2016]

MICAL2 Products (16)

mRNA	Protein	Name
NM_001282663.2	NP_001269592.1	[F-actin]-monooxygenase MICAL2 isoform a
NM_001282664.1	NP_001269593.1	[F-actin]-monooxygenase MICAL2 isoform b
NM_001282665.1	NP_001269594.1	[F-actin]-monooxygenase MICAL2 isoform c
NM_001282666.1	NP_001269595.1	[F-actin]-monooxygenase MICAL2 isoform d
NM_001282667.1	NP_001269596.1	[F-actin]-monooxygenase MICAL2 isoform e
NM_001282668.2	NP_001269597.1	[F-actin]-monooxygenase MICAL2 isoform f
NM_001346292.2	NP_001333221.1	[F-actin]-monooxygenase MICAL2 isoform a
NM_001346293.2	NP_001333222.1	[F-actin]-monooxygenase MICAL2 isoform b
NM_001346294.2	NP_001333223.1	[F-actin]-monooxygenase MICAL2 isoform b
NM_001346295.2	NP_001333224.1	[F-actin]-monooxygenase MICAL2 isoform b
NM_001346296.2	NP_001333225.1	[F-actin]-monooxygenase MICAL2 isoform b
NM_001346297.2	NP_001333226.1	[F-actin]-monooxygenase MICAL2 isoform b
NM_001346298.2	NP_001333227.1	[F-actin]-monooxygenase MICAL2 isoform b
NM_001346299.2	NP_001333228.1	[F-actin]-monooxygenase MICAL2 isoform b
NM_001393937.1	NP_001380866.1	[F-actin]-monooxygenase MICAL2 isoform g
NM_014632.4	NP_055447.1	[F-actin]-monooxygenase MICAL2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables actin binding	IDA IDA: Inferred from direct assay	24440334	GOA
enables monooxygenase activity	IDA IDA: Inferred from direct assay	29343822	GOA
enables oxidoreductase activity	IDA IDA: Inferred from direct assay	24440334	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in actin filament depolymerization	IDA IDA: Inferred from direct assay	24440334	GOA
involved in cytoskeleton organization	IDA IDA: Inferred from direct assay	24440334	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	24440334	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
is active in actin filament	IDA IDA: Inferred from direct assay	29343822	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24440334	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MICAL2 Protein Structure

FAD_binding_3

CH

LIM

0
200
400
600
800
1000
1124 a.a.

Protein Preferred Names	Protein Names
[F-actin]-monooxygenase MICAL2	ERK2-binding testicular protein 1

Related Diseases

Diseases	Alias
Trimethylaminuria	TMAU Fish-Odor Syndrome Fish Malodor Syndrome Fish Odor Syndrome Stale Fish Syndrome Tmauria Severe Primary Trimethylaminuria Mesh D008661 Fish Odour Syndrome
Griscelli Syndrome	Chediak-Higashi-Like Syndrome Griscelli-Prunieras Syndrome Partial Albinism-Immunodeficiency Syndrome Griscelli Disease Gs Hypopigmentation Immunodeficiency Disease Partial Albinism With Immunodeficiency Immunodeficiency Syndrome With Hypopigmentation Hypopigmentation-Immunodeficiency Disease
Mitral Valve Insufficiency	Mitral Regurgitation Congenital Insufficiency Of Mitral Valve Congenital Mitral Insufficiency Congenital Mitral Regurgitation Mitral Valve Incompetence Mitral Valve Regurgitation Mr - [Mitral Regurgitation] Mi - [Mitral Incompetence] Mitral Valve Annular Incompetency Congenital Mitral Valve Incompetence Congenital Mitral Valve Insufficiency Congenital Mitral Valve Regurgitation Congenital Mitral Incompetence

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Referencia número	Nombre del producto	Efecto	Pureza	Phase
HY-P0107	RC-3095	Antagonist	99.43%	Phase 2
HY-145119S	Mindeudesivir		98.20%	Phase 1

Pre-clinical Phase

Bioactive Molecules (27)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-P0107A	RC-3095 TFA	Antagonist	99.66%	Unkown
HY-103316A	Ned 19	Inhibitor	99.92%	Unkown
HY-12736A	GSK143 dihydrochloride	Inhibitor	99.37%	Unkown
HY-109506S	DPPC-d62		99.0%	Unkown
HY-W010516	2-Methylvaleric acid		99.98%	Unkown
HY-W654264	2-Methylbutyrylcarnitine chloride	Activator	98.92%	Unkown
HY-N1393	2-Methoxybenzoic acid	Inhibitor	99.86%	Unkown
HY-75625	2-Hydroxy-4-methoxybenzoic acid		99.64%	Unkown
HY-109506S1	DPPC-d9		98.0%	Unkown
HY-109506S3	DPPC-d9-1		≥99.0%	Unkown
HY-109506S9	DPPC-13C2		95.0%	Unkown
HY-131102	Mequindox	Inhibitor	99.62%	Unkown
HY-N1393R	2-Methoxybenzoic acid (Standard)		/	Unkown
HY-101139	Xanthine amine congener	Antagonist	/	Unkown
HY-113902	(2-(β-Piperidinoethyl)-9-hydroxyellipticinium chloride	Inhibitor	/	Unkown
HY-12736	GSK143	Inhibitor	/	Unkown
HY-162720	NNRT-IN-4	Inhibitor	/	Unkown
HY-B0448S1	Phenytoin-15N2,13C		99.84%	Unkown
HY-D0195S	Acesulfame-d4 potassium		99.72%	Unkown
HY-N1393S1	2-Methoxybenzoic acid-d3		/	Unkown
HY-RS08426	MICAL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-109506S2	(Rac)-DPPC-d6		98.0%	Unkown
HY-184378	MDB5		/	Unkown
HY-B0281AS	Ranitidine-d6 hydrochloride	Antagonist	97.00%	Unkown
HY-N1393S	2-Methoxybenzoic acid-13C6		/	Unkown
HY-RS20179	Mical2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26683	Mical2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MICAL2	VGNC	VGNC:103135
Macaca mulatta	MICAL2	VGNC	VGNC:101352
Bos taurus	MICAL2	VGNC	VGNC:31458
Rattus norvegicus	MICAL2	RGD	RGD:1311773
Canis familiaris	MICAL2	VGNC	VGNC:106605
Mus musculus	MICAL2	MGD	MGI:2444947
Others	MICAL2	NCBI