2. Membrane Transporter/Ion Channel
  3. Monoamine Transporter
  4. GZ-11608

GZ-11608 is a potent and selective vesicular monoamine transporter-2 (VMAT2) inhibitor with high affinity (Ki = 25 nM). GZ-11608 decreases methamphetamine-induced dopamine release from isolated synaptic vesicles from brain dopaminergic neurons. GZ-11608 exhibits rapid brain penetration and without neurotoxicity. GZ-11608 can be used for the research of methamphetamine use disorder.

For research use only. We do not sell to patients.

GZ-11608 Chemical Structure

GZ-11608 Chemical Structure

CAS No. : 2141974-01-6

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Description

GZ-11608 is a potent and selective vesicular monoamine transporter-2 (VMAT2) inhibitor with high affinity (Ki = 25 nM). GZ-11608 decreases methamphetamine-induced dopamine release from isolated synaptic vesicles from brain dopaminergic neurons. GZ-11608 exhibits rapid brain penetration and without neurotoxicity. GZ-11608 can be used for the research of methamphetamine use disorder[1].

IC50 & Target

Ki: 25 nM (VMAT2)[1]
Molecular Weight

283.41

Formula

C19H25NO
CAS No.
SMILES

C[C@H](NCCCC1=CC=C(OC)C=C1)CC2=CC=CC=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GZ-11608 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GZ-116082141974-01-6GZ11608GZ 11608Monoamine Transporterselective vesicular monoamine transporter-2 (VMAT2)dopaminergic neuronsneurotoxicitymethamphetamineInhibitorinhibitorinhibit

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