2141974-01-6
Chemical Structure
GZ-11608
- CAS No.: 2141974-01-6
- Formula:C19H25NO
- Molecular Weight:283.41
IUPAC Name: (S)-3-(4-methoxyphenyl)-N-(1-phenylpropan-2-yl)propan-1-amine
InChIKey: LKTLDVZCNLGHOG-INIZCTEOSA-N
SMILES: C[C@H](NCCCC1=CC=C(OC)C=C1)CC2=CC=CC=C2
Biological Activity: GZ-11608 is a potent and selective vesicular monoamine transporter-2 (VMAT2) inhibitor with high affinity (Ki = 25 nM). GZ-11608 decreases methamphetamine-induced dopamine release from isolated synaptic vesicles from brain dopaminergic neurons. GZ-11608 exhibits rapid brain penetration and without neurotoxicity. GZ-11608 can be used for the research of methamphetamine use disorder[1].
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GZ-11608 | GZ-11608 is a potent and selective vesicular monoamine transporter-2 (VMAT2) inhibitor with high affinity (Ki = 25 nM). GZ-11608 decreases methamphetamine-induced dopamine release from isolated synaptic vesicles from brain dopaminergic neurons. GZ-11608 exhibits rapid brain penetration and without neurotoxicity. GZ-11608 can be used for the research of methamphetamine use disorder. | |||||||||||||||||||||
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Keywords
