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Cat. No.: HY-183926

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D719

D719 is an HIV-1 integrase inhibitor. D719 binds to the hydrophobic pocket of HIV-1 integrase CCD dimer, disrupts interaction with LEDGF/P75, and prevents integrase nuclear translocation. D719 reduces HIV-1 p24 antigen production in acute infection of human T cells. D719 can be used for the research of HIV infection.

For research use only. We do not sell to patients.

CAS No.: 384361-09-5
Formula: C₂₁H₂₀N₂O₅S
Molecular Weight:412.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

D719 Chemical Structure

CAS No.: 384361-09-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

D719 (1 μM; from 5 h post-transfection until fixation the next day) inhibits nuclear translocation of EGFP-tagged HIV-1 integrase in HeLa Tet-Off Advanced Cells^[1].
D719 (10 μM; from 5 h post-transfection until fixation the next day) inhibits nuclear translocation of native HIV-1 integrase in HeLa Tet-Off Advanced Cells^[1].
D719 (0.5-20 μM; 3 days post-infection) inhibits HIV-1 replication in acutely infected C8166 T cells, reducing p24 antigen production with an EC₅₀ of 4.33 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:

HeLa Tet-Off Advanced Cells
Concentration:

10 μM
Incubation Time:

from 5 h post-transfection until fixation the next day
Result:

Prevented native integrase from localizing to the nucleus, confirming inhibition of nuclear translocation independent of EGFP interactions.

Chemical Information

CAS No. 384361-09-5
Molecular Weight 412.46
Formula C₂₁H₂₀N₂O₅S
SMILES

O=C1OC2=C(CN(CCO)CCO)C(O)=CC=C2C=C1C3=NC4=C(S3)C=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gu WG, et al. Discovery of a novel HIV-1 integrase inhibitor from natural compounds through structure based virtual screening and cell imaging. FEBS Lett. 2014;588(18):3461-3468. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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