Torvutatug
Based on 1 Customer Validation
Torvutatug (AZD5335 Antibody) is a human IgG1 κ monoclonal antibody against FRα, with an IC50 value of 7.4 nM against hFRα. Torvutatug can serve as an ADC antibody for the synthesis of ADC, such as AZD5335. Torvutatug is applicable to ovarian cancer-related research.
For research use only. We do not sell to patients.
- Purity: 99%
- CAS No.: 2975630-15-8
- Molecular Weight:145.532 kDa
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Human IgG1 kappa
Human
|
FRα 7.4 nM (IC50) |
Torvutatug binds specifically to cynomolgus monkey FRα, and shows no cross-reactivity with non-target folate receptor paralogs or rodent FRα[1].
Torvutatug exhibits similarly high affinity for cynomolgus monkey FRα, but extremely low affinity for mouse FRα[1].
Torvutatug binds to cell-surface FRα with high specificity, and exhibits negligible off-target binding to DLL1 only at extremely high concentrations[1].
Torvutatug (up to 8 h) is rapidly internalized and trafficked to lysosomes in FRα-expressing KB cells, and its internalization level is significantly higher than that of the isotype control antibody[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
-
IgG1-kappa
ELISA, FACS, Functional assay
-
Loaded Torvutatug on ProA biosensor, can bind HY-P70296 FOLR1 Protein, Human (HEK293, His) with an affinity constant of 2.582E-08 M as determined in BLI assay.
Chemical Information
-
CAS No. 2975630-15-8
-
Appearance Liquid
-
Molecular Weight 145.532 kDa
-
Color Colorless to light yellow
-
SMILES
[Torvutatug]
-
Synonyms
AZD5335 Antibody; INT-019
-
Shipping
Shipping with dry ice.
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
-
Data Sheet (258 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Torvutatug Related Classifications
HY-P991164 Related Classifications
Powered by Bioz