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Cat. No.: HY-144005

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C16 PEG2000 Ceramide

(Synonyms: C16 PEG Ceramide (MW 2000))

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Based on 1 Customer Validation

C16 PEG2000 Ceramide is a polyethylene glycolylated ceramide. C16 PEG2000 Ceramide can be used for lipid carrier to delivery. C16 PEG2000 Ceramide induces autophagy. C16 PEG2000 Ceramide can be used for cancer research.

For research use only. We do not sell to patients.

Purity: 99.37%
CAS No.: 212116-78-4
Formula: (C₂H₄O)nC₃₉H₇₃NO₆
Molecular Weight:2000 (Average)

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

C16 PEG2000 Ceramide Chemical Structure

CAS No.: 212116-78-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

C16 PEG2000 Ceramide (0-118.6μM, 24 hours) has cytotoxicity and promotes autophagy in N2a cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[2].

Cell Line:

N2a cells
Concentration:

3.7-118.6 μM
Incubation Time:

24 hours
Result:

Inhibits N2a cells activity in a dose-dependent.

Western Blot Analysis^[2].

Cell Line:

N2a cells
Concentration:

2.5, 5.0, 10 and 20 μM
Incubation Time:

24 hours
Result:

Increased the LC3-II/LC3-I ratios, reduced the content of WT-Tau and P301L-Tau proteins in the cells.

Chemical Information

CAS No. 212116-78-4
Appearance Solid
Molecular Weight 2000 (Average)
Formula (C₂H₄O)nC₃₉H₇₃NO₆
Color White to off-white
SMILES

O=C(CCC(OC[C@@H]([C@@H](/C=C/CCCCCCCCCCCCC)O)NC(CCCCCCCCCCCCCCC)=O)=O)OCCOC.[n]
Synonyms

C16 PEG Ceramide (MW 2000)
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

Ethanol : 100 mg/mL (Need ultrasonic)

View the Complete Stock Solution Preparation Table

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Su X, et, al. Co-delivery of doxorubicin and PEGylated C16-ceramide by nanoliposomes for enhanced therapy against multidrug resistance. Nanomedicine (Lond). 2015;10(13):2033-50. [Content Brief]

[2]. Gao J, et, al. PEG-Ceramide Nanomicelles Induce Autophagy and Degrade Tau Proteins in N2a Cells. Int J Nanomedicine. 2020 Sep 11;15:6779-6789.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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