FKBP5 - FKBP prolyl isomerase 5 Gene

Also Known as P54; AIG6; FKBP51; FKBP54; PPIase; Ptg-10

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2289

About FKBP5

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:35,573,590-35,728,583 (from NCBI)

This gene has 4 transcripts (splice variants), 210 orthologues, 18 paralogues and is associated with 1 phenotype. Broad expression in fat (RPKM 97.5), lymph node (RPKM 33.3) and 18 other tissues.

Summary

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate Calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric Progesterone Receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

FKBP5 Products (4)

mRNA	Protein	Name
NM_001145775.3	NP_001139247.1	peptidyl-prolyl cis-trans isomerase FKBP5 isoform 1
NM_001145776.2	NP_001139248.1	peptidyl-prolyl cis-trans isomerase FKBP5 isoform 1
NM_001145777.2	NP_001139249.1	peptidyl-prolyl cis-trans isomerase FKBP5 isoform 2
NM_004117.4	NP_004108.1	peptidyl-prolyl cis-trans isomerase FKBP5 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	9660753	GOA
enables peptidyl-prolyl cis-trans isomerase activity	IDA IDA: Inferred from direct assay	11350175	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14676191	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	28147277	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in chaperone-mediated protein folding	IDA IDA: Inferred from direct assay	11350175	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FKBP5 Protein Structure

FKBP_C

TPR_11

0
100
200
300
400
457 a.a.

Protein Preferred Names	Protein Names
peptidyl-prolyl cis-trans isomerase FKBP5	51 kDa FK506-binding protein

FKBP5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FKBP5	Q13451	PYGB	Homo sapiens	P11216	Anti Tag CoIP	35271311
Intra	FKBP5	Q13451	CDK9	Homo sapiens	P50750	Anti Tag CoIP	35271311
Intra	FKBP5	Q13451	CDK9	Homo sapiens	P50750	Anti Tag CoIP	25036637
Intra	FKBP5	Q13451	HSP90AA1	Homo sapiens	P07900	X-Ray Diffraction	29079741
Intra	FKBP5	Q13451	HSP90AA1	Homo sapiens	P07900	DSC	29079741
Intra	FKBP5	Q13451	HSP90AA1	Homo sapiens	P07900	Anti Tag CoIP	35271311
Intra	FKBP5	Q13451	EGFR	Homo sapiens	P00533	Lumier	25036637
Intra	FKBP5	Q13451	STK11	Homo sapiens	Q15831	Lumier	25036637
Intra	FKBP5	Q13451	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	35271311
Intra	FKBP5	Q13451	HSP90AB1	Homo sapiens	P08238	NMR	30382094
Intra	FKBP5	Q13451	HSP90AB1	Homo sapiens	P08238	Solution Sedimentation	21170051
Intra	FKBP5	Q13451	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	25036637
Intra	FKBP5	Q13451	HSP90AB1	Homo sapiens	P08238	SAXS	30382094
Intra	FKBP5	Q13451	HSP90AB1	Homo sapiens	P08238	Fluorescence	30382094
Intra	FKBP5	Q13451	HSP90AB1	Homo sapiens	P08238	Comigration in SDS	30382094
Intra	FKBP5	Q13451	HSP90AB1	Homo sapiens	P08238	Crosslink	30382094
Intra	FKBP5	Q13451	MCM7	Homo sapiens	P33993	Anti Tag CoIP	35271311
Intra	FKBP5	Q13451	MAPT	Homo sapiens	P10636-8	Comigration in SDS	30382094
Intra	FKBP5	Q13451	MAPT	Homo sapiens	P10636-8	NMR	30382094
Intra	FKBP5	Q13451	MAPT	Homo sapiens	P10636-8	Fluorescence	30382094
Intra	FKBP5	Q13451	MAPT	Homo sapiens	P10636-8	Crosslink	30382094
Intra	FKBP5	Q13451	MAPT	Homo sapiens	P10636-8	SAXS	30382094
Intra	FKBP5	Q13451	KSR2	Homo sapiens	Q6VAB6	Lumier	25036637
Intra	FKBP5	Q13451	CHUK	Homo sapiens	O15111	Anti Tag CoIP	14743216
Intra	FKBP5	Q13451	CHUK	Homo sapiens	O15111	TAP	14743216
Intra	FKBP5	Q13451	CHUK	Homo sapiens	O15111	Anti Tag CoIP	33961781
Intra	FKBP5	Q13451	CHUK	Homo sapiens	O15111	Anti Tag CoIP	35271311
Intra	FKBP5	Q13451	CHUK	Homo sapiens	O15111	Anti Tag CoIP	25036637
Intra	FKBP5	Q13451	MCMBP	Homo sapiens	Q9BTE3-2	Lumier	25036637
Intra	FKBP5	Q13451	MCMBP	Homo sapiens	Q9BTE3-2	Validated Y2H	32296183
Cross	FKBP5	Q13451	Q9WMX2-PRO_0000037552	Hepatitis C virus	Q9WMX2-PRO_0000037552	Pull Down	24169621

Cross: Cross-species interaction Intra: Intraspecies interaction

FKBP5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80401	FKBP51 Antibody (YA433)	WB, IHC-P, IP, FC	Human, Rat

Related Diseases

Diseases	Alias
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Borderline Personality Disorder
Acute Stress Disorder	Traumatic Stress Disorder Stress Disorders, Traumatic, Acute Stress Disorders, Traumatic
Myelofibrosis	Primary Myelofibrosis Agnogenic Myeloid Metaplasia Idiopathic Myelofibrosis Myeloid Metaplasia Myelofibrosis With Myeloid Metaplasia Osteomyelofibrosis Megakaryocytic Myelosclerosis Myelosclerosis Chronic Idiopathic Myelofibrosis Myelofibrosis, Idiopathic Myelofibrosis With Myeloid Metaplasia, Somatic Myelofibrosis, Somatic Aleukemic Myelosis Bone Marrow Fibrosis MYELOF MMM Agnogenic Myeloid Metaplasia With Myelofibrosis Ammm Myelosclerosis With Myeloid Metaplasia Myelofibrosis Nos
Personality Disorder	Personality Disorders Character Disorder Personality Specific Personality Disorders Enduring Personality Change After Psychiatric Illness
Ocular Hypertension	Hypertension, Ocular Intraocular Pressure Increase Oh - [Ocular Hypertension] Oht - [Ocular Hypertension]
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Obsessive-Compulsive Disorder	OCD Obsessive-Compulsive Disorder, Susceptibility To Anancastic Neurosis Obsessive Compulsive Disorder Anankastic Neurosis Obsessive-Compulsive Neurosis Obsessive Compulsive Behavior
Dissociative Disorder	Dissociative Disorders Dissociative Disease Dissociative Reaction
Post-Traumatic Stress Disorder	PTSD Traumatic Neurosis Post Traumatic Stress Disorder Stress Disorders, Post-Traumatic Posttraumatic Stress Disorder Ptsd - [Post Traumatic Stress Disorder] Trauma-Related Disorders
Mental Depression	Depression Depressive Disorder
Atypical Depressive Disorder	Atypical Depression
Dissociative Amnesia	Psychogenic Amnesia Amnesia, Dissociative Amnesia, Psychogenic Amnesia Neurosis Hysterical Fugue Dissociative Fugue
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Endogenous Depression	Clinical Depression Unipolar Depression Depressive Disorder
Phobia, Specific	Specific Phobia Simple Phobia Phobia, Simple Isolated Phobia
Rett Syndrome	Atypical Rett Syndrome RTT Rett Disorder Rts Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use Rett Syndrome, Preserved Speech Variant Rett Syndrome, Atypical Rett'S Disorder Rett Syndrome Variant Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome Cerebroatrophic Hyperammonemia Rett Like Syndrome Rett'S Syndrome Atypical Rtt Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Rett Syndrome Preserved Speech Variant Rett Syndrome Zappella Variant Rett Syndrome, Zappella Variant
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Skin Atrophy	Atrophic Condition Of Skin Atrophoderma Atrophy - Skin
Phobic Disorder	Phobic Disorders Phobic Anxiety Disorder
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Mood Disorder	Mood Disorders Episodic Mood Disorder
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-135794	11-Ketodihydrotestosterone	Agonist	99.87%	Unkown
HY-136242	UT-34	Degrader	98.09%	Unkown
HY-RS04965	FKBP5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16916	Fkbp5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23358	Fkbp5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FKBP5	MGD	MGI:104670
Rattus norvegicus	FKBP5	RGD	RGD:1309155
Bos taurus	FKBP5	VGNC	VGNC:29024
Canis familiaris	FKBP5	VGNC	VGNC:40891
Macaca mulatta	FKBP5	VGNC	VGNC:72665
Felis catus	FKBP5	VGNC	VGNC:62281
Others	FKBP5	NCBI