KSR2 - kinase suppressor of ras 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 283455

About KSR2

Cytogenetic location: 12q24.22-q24.23 Genomic coordinates (GRCh38): 12:117,453,012-117,968,990 (from NCBI)

This gene has 4 transcripts (splice variants), 196 orthologues, 23 paralogues and is associated with 1 phenotype. Biased expression in brain (RPKM 1.7), adrenal (RPKM 0.5) and 7 other tissues.

Summary

Predicted to enable MAP-kinase scaffold activity; mitogen-activated protein kinase kinase binding activity; and protein kinase activity. Predicted to be involved in Ras protein signal transduction; calcium-mediated signaling; and positive regulation of cold-induced thermogenesis. Predicted to act upstream of or within positive regulation of MAPK cascade. Predicted to be active in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

KSR2 Products (1)

mRNA Protein Name
NM_173598.6 NP_775869.4 kinase suppressor of Ras 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21441910 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
21441910 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KSR2 Protein Structure

KSR1-SAM

KSR1-SAM: SAM like domain present in kinase suppressor RAS 1 (24 - 152)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (666 - 928)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 950 a.a.
Protein Preferred Names Protein Names

kinase suppressor of Ras 2

KSR2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KSR2 Q6VAB6 CDC37 Homo sapiens Q16543
Lumier
25036637
Intra
KSR2 Q6VAB6 CDC37 Homo sapiens Q16543
Pull Down
32707033
Intra
KSR2 Q6VAB6 CDC37 Homo sapiens Q16543
Anti Tag CoIP
27086506
Intra
KSR2 Q6VAB6 HSP90AA1 Homo sapiens P07900
Pull Down
32707033
Intra
KSR2 Q6VAB6 HSP90AA1 Homo sapiens P07900
Anti Tag CoIP
27086506
Intra
KSR2 Q6VAB6 FKBP5 Homo sapiens Q13451
Pull Down
32707033
Intra
KSR2 Q6VAB6 FKBP5 Homo sapiens Q13451
Anti Tag CoIP
27086506
Intra
KSR2 Q6VAB6 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
KSR2 Q6VAB6 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100627 APS-2-79 Antagonist 99.38% Unkown
HY-100627A APS-2-79 hydrochloride Antagonist 98.42% Unkown
HY-RS02889 CNKSR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07476 KSR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris KSR2 VGNC VGNC:42548
Mus musculus KSR2 MGD MGI:3610315
Macaca mulatta KSR2 VGNC VGNC:74075
Bos taurus KSR2 VGNC VGNC:30755
Rattus norvegicus KSR2 RGD RGD:1562674
Felis catus KSR2 VGNC VGNC:63178
Others KSR2 NCBI