NFATC4 - nuclear factor of activated T cells 4 Gene

Also Known as NFAT3; NF-AT3; NF-ATC4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4776

About NFATC4

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,366,911-24,379,604 (from NCBI)

This gene has 33 transcripts (splice variants), 1 gene allele, 182 orthologues and 4 paralogues. Broad expression in ovary (RPKM 15.2), endometrium (RPKM 13.8) and 22 other tissues.

Summary

This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent Phosphatase, Calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

NFATC4 Products (9)

mRNA Protein Name
NM_001136022.3 NP_001129494.1 nuclear factor of activated T-cells, cytoplasmic 4 isoform 1
NM_001198965.2 NP_001185894.1 nuclear factor of activated T-cells, cytoplasmic 4 isoform 3
NM_001198966.2 NP_001185895.1 nuclear factor of activated T-cells, cytoplasmic 4 isoform 4
NM_001198967.3 NP_001185896.1 nuclear factor of activated T-cells, cytoplasmic 4 isoform 5
NM_001288802.2 NP_001275731.1 nuclear factor of activated T-cells, cytoplasmic 4 isoform 6
NM_001320043.2 NP_001306972.1 nuclear factor of activated T-cells, cytoplasmic 4 isoform 7
NM_001363681.1 NP_001350610.1 nuclear factor of activated T-cells, cytoplasmic 4 isoform 8
NM_001363682.1 NP_001350611.1 nuclear factor of activated T-cells, cytoplasmic 4 isoform 9
NM_004554.5 NP_004545.2 nuclear factor of activated T-cells, cytoplasmic 4 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IGI
IGI: Inferred from genetic interaction
23543060 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18218901 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of miRNA transcription IGI
IGI: Inferred from genetic interaction
23543060 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
12370307 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NFATC4 Protein Structure

RHD_DNA_bind

RHD_DNA_bind: Rel homology DNA-binding domain (419 - 578)

TIG

TIG: IPT/TIG domain (586 - 682)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 902 a.a.
Protein Preferred Names Protein Names

nuclear factor of activated T-cells, cytoplasmic 4

  • T-cell transcription factor NFAT3

NFATC4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NFATC4 Q14934 UBC Homo sapiens P0CG48
Pull Down
19026640
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Leukostasis
Noonan Syndrome With Multiple Lentigines

  • Leopard Syndrome

  • Multiple Lentigines Syndrome

  • Moynahan Syndrome

  • Cardiomyopathic Lentiginosis

  • Progressive Cardiomyopathic Lentiginosis

  • Cardio-Cutaneous Syndrome

  • Lentiginosis Profusa

  • Capute-Rimoin-Konigsmark-Esterly-Richardson Syndrome

  • Generalized Lentiginosis

  • Gorlin Syndrome Ii

  • Lentiginosis Profusa Syndrome

  • Lentigines, Electrocardiographic Conduction Abnormalities, Ocular Hypertelorism, Pulmonic Stenosis, Abnormal Genitalia, Retardation Of Growth, Deafnes

  • Diffuse Lentiginosis

  • Nsml

  • Familial Multiple Lentigines Syndrome

  • Alopecia-Epilepsy-Intellectual Disability Syndrome, Moynahan Type

  • Progressive Cardiomyopathic Lentiginosis Syndrome

  • Alopecia Epilepsy Oligophrenia Syndrome Of Moynahan
Dilated Cardiomyopathy

  • Familial Dilated Cardiomyopathy

  • Primary Dilated Cardiomyopathy

  • Idiopathic Dilated Cardiomyopathy

  • Congestive Cardiomyopathy

  • Idiopathic Dilation Cardiomyopathy

  • Primary Familial Dilated Cardiomyopathy

  • Cardiomyopathy, Dilated

  • DCM

  • Cardiomyopathy, Familial Dilated

  • Dilated Cardiomyopathy, Familial

  • Hypokinetic Dilated Cardiomyopathy, Familial

  • Familial Idiopathic Cardiomyopathy

  • Fdc

  • Cardiomyopathy, Familial Idiopathic

  • Idiopathic Cardiomegaly

  • Dilated Congestive Cardiomyopathy

  • Chronic Dilated Cardiomyopathy

  • Ccm - [Congestive Cardiomyopathy]

  • Cocm - [Congestive Cardiomyopathy]

  • Dcm - [Dilated Cardiomyopathy]

  • Dilated-Hypokinetic Cardiomyopathy

  • Congestive Idiopathic Cardiomyopathy

  • Primary Idiopathic Dilated Cardiomyopathy
Rasopathy

  • Ras/Mitogen-Activated Protein Kinase Syndrome
Hypertrophic Cardiomyopathy

  • Hypertrophic Obstructive Cardiomyopathy

  • Cardiomyopathy, Hypertrophic

  • Cardiomyopathy Hypertrophic Obstructive

  • Cardiomyopathy, Hypertrophic, Familial

  • Idiopathic Myocardial Hypertrophy

  • Idiopathic Hypertrophic Cardiomyopathy

  • Obstructive Idiopathic Hypertrophic Cardiomyopathy

  • Obstructive Cardiomyopathy

  • Idiopathic Hypertrophic Subaortic Stenosis

  • Muscular Subaortic Stenosis

  • Hypertrophic Obstructive Subaortic Stenosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P0254 Kisspeptin-10, human 99.86% Unkown
HY-P0254A Kisspeptin-10, human TFA 99.56% Unkown
HY-N1910 4'-O-Methylbavachalcone Inhibitor 99.64% Unkown
HY-RS09242 NFATC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21899 Nfatc4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28416 Nfatc4 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NFATC4 MGD MGI:1920431
Felis catus NFATC4 VGNC VGNC:68472
Rattus norvegicus NFATC4 RGD RGD:1310749
Bos taurus NFATC4 VGNC VGNC:54464
Canis familiaris NFATC4 VGNC VGNC:43770
Macaca mulatta NFATC4 VGNC VGNC:75329
Others NFATC4 NCBI