FABP1 - fatty acid binding protein 1 Gene

Also Known as FABPL; L-FABP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2168

About FABP1

Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:88,122,982-88,128,062 (from NCBI)

This gene has 4 transcripts (splice variants), 270 orthologues and 15 paralogues. Biased expression in liver (RPKM 2613.3), colon (RPKM 1932.3) and 3 other tissues.

Summary

This gene encodes the fatty acid binding protein found in liver. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and Other hydrophobic ligands. This protein and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Mar 2011]

FABP1 Products (1)

mRNA	Protein	Name
NM_001443.3	NP_001434.1	fatty acid-binding protein, liver

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables antioxidant activity	IDA IDA: Inferred from direct assay	16175609	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to hydrogen peroxide	IDA IDA: Inferred from direct assay	16175609	GOA
involved in cellular response to hypoxia	IDA IDA: Inferred from direct assay	16175609	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	16175609	GOA
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	16175609	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FABP1 Protein Structure

Lipocalin_7

0
100
127 a.a.

Protein Preferred Names	Protein Names
fatty acid-binding protein, liver	fatty acid binding protein 1, liver

FABP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FABP1	P07148	GNPNAT1	Homo sapiens	Q96EK6	Anti Tag CoIP	33961781
Intra	FABP1	P07148	GNPNAT1	Homo sapiens	Q96EK6	Anti Tag CoIP	28514442
Intra	FABP1	P07148	FLNA	Homo sapiens	P21333-2	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FABP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70264	FABP1/L-FABP Protein, Human (His)	P07148 (M1-I127)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70264A	FABP1/L-FABP Protein, Human (His, solution)	P07148 (M1-I127)	≥ 95%, as determined by reducing SDS-PAGE.

FABP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81273	liver FABP Antibody (YA965)	ELISA	Human
HY-P81273A	liver FABP Antibody (YA965)(PBS only)	ELISA	Human
HY-P81523	liver FABP Antibody (YA1268)	IHC-P	Human
HY-P81523A	liver FABP Antibody (YA1268)(PBS only)	IHC-P	Human
HY-P85633	liver FABP Antibody (YA5325)	ELISA	Human

Related Diseases

Diseases	Alias
Hepatocellular Adenoma	Adenoma Hepatocellular
Liver Benign Neoplasm	Epithelial Hepatic And Intrahepatic Bile Duct Neoplasm
Type 1 Diabetes Mellitus 19	Diabetes Mellitus, Insulin-Dependent, 19 IDDM19 T1D19 Insulin-Dependent Diabetes Mellitus 19
Chylomicron Retention Disease	CMRD Anderson Disease Lipid Transport Defect Of Intestine Hypobetalipoproteinemia With Accumulation Of Apolipoprotein B-Like Protein In Intestinal Cells Andd Anderson Syndrome Crd Andersons Disease Malabsorption Syndrome
Chronic Kidney Disease	Chronic Renal Disease Chronic Kidney Failure Ckd Chronic Renal Failure Kidney Failure, Chronic Chronic Renal Failure Syndrome Crf Renal Failure - Chronic Renal Failure Chronic Chronic Kidney Diseases Chronic Kidney Disease Stage 5 Ckd - [Chronic Kidney Disease] Crf - [Chronic Renal Failure] Chronic Kidney Impairment Chronic Renal Impairment Chronic Kidney Shutdown Chronic Hypoxic Kidney Failure Chronic Kidney Collapse Chronic Renal Insufficiency Chronic Kidney Toxaemia Chronic Kidney Hypofunction Chronic Renal Suppression Chronic Renal Failure, Stage 5 Ckd - [Chronic Kidney Disease] Stage 5 End Stage Kidney Failure End Stage Renal Failure End Stage Kidney Disease End Stage Renal Disease End Stage Chronic Renal Failure Esrf - [End Stage Renal Failure] Esrd - [End Stage Renal Diseases] Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Ureteral Obstruction
Non-Alcoholic Fatty Liver Disease	Fatty Liver Non-Alcoholic Fatty Liver Nafld Nonalcoholic Fatty Liver Disease Nonalcoholic Steatohepatitis Steatosis Nafl Nash Non-Alcoholic Steatohepatitis Susceptibility To Nonalcoholic Fatty Liver Disease Steatohepatitis Fatty Degeneration Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis Nafld Without Nash Nafld Without Mention Of Nash
Kidney Disease	Renal Failure Kidney Failure Kidney Diseases Nephropathy Abnormality Of The Kidney Impaired Renal Function Disease Renal Anomaly Kidney Dysfunction Renal Disease Nephropathies Renal Failure Adverse Event Abnormal Renal Function
Acute Kidney Tubular Necrosis	Acute Tubular Necrosis Acute Renal Failure With Tubular Necrosis Acute Tubule Necrosis Acute Renal Failure With Lesion Of Tubular Necrosis Atn - Acute Tubular Necrosis Tubular Necrosis Acute Kidney Tubular Necrosis, Acute Acute Renal Tubular Necrosis Acute Tubular Nephrosis Ischaemic Acute Tubular Necrosis Ischaemic Tubular Necrosis Kidney Tubular Necrosis Lower Nephron Nephrosis Necrotising Renal Oedema Renal Tubular Necrosis Toxic Tubular Necrosis Tubular Kidney Necrosis Tubular Necrosis Nos Tubular Nephrosis
Maturity-Onset Diabetes Of The Young, Type 3	Maturity-Onset Diabetes Of The Young Type 3 MODY3 Mody, Type Iii Mody Type 3 Mody, Type 3 Maturity-Onset Diabetes Of The Young 3 Mody-3 Diabetes Of The Young, Maturity-Onset, Type 3
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Diabetes Mellitus	Diabetes
Maturity-Onset Diabetes Of The Young	MODY Maturity Onset Diabetes Mellitus In Young Mason-Type Diabetes Mason Type Diabetes Maturity Onset Diabetes Of The Young Mody Syndrome Diabetes Of The Young, Maturity-Onset
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-158127	FABP1-IN-1	Inhibitor	99.95%	Unkown
HY-127049	Arachidonic acid-biotin		98.71%	Unkown
HY-149831	ZLY28	Modulator	99.95%	Unkown
HY-172883	ABP/PPAR modulator 1	Modulator	/	Unkown
HY-161892	FABP4-IN-4	Inhibitor	/	Unkown
HY-172883A	(E/Z)-ABP/PPAR modulator 1	Modulator	97.22%	Unkown
HY-D2857	NBD-Stearic acid		/	Unkown
HY-RS04656	FABP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17252	Fabp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23706	Fabp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FABP1	VGNC	VGNC:106161
Bos taurus	FABP1	VGNC	VGNC:28695
Canis familiaris	FABP1	VGNC	VGNC:40558
Felis catus	FABP1	VGNC	VGNC:62034
Mus musculus	FABP1	MGD	MGI:95479
Rattus norvegicus	FABP1	RGD	RGD:2590
Others	FABP1	NCBI