GNPNAT1 - glucosamine-phosphate N-acetyltransferase 1 Gene

Also Known as GNA1; GNPNAT; Gpnat1; RHZDAN

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64841

About GNPNAT1

Cytogenetic location: 14q22.1 Genomic coordinates (GRCh38): 14:52,775,193-52,791,607 (from NCBI)

This gene has 6 transcripts (splice variants) and 219 orthologues. Ubiquitous expression in liver (RPKM 17.9), colon (RPKM 9.0) and 25 other tissues.

Summary

Enables identical protein binding activity. Predicted to be involved in UDP-N-acetylglucosamine biosynthetic process. Predicted to act upstream of or within cellular response to Leukemia Inhibitory Factor. Predicted to be located in late endosome. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Apr 2022]

GNPNAT1 Products (1)

mRNA Protein Name
NM_198066.4 NP_932332.1 glucosamine 6-phosphate N-acetyltransferase

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
18675810 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNPNAT1 Protein Structure

Acetyltransf_1

Acetyltransf_1: Acetyltransferase (GNAT) family (95 - 171)

  • 0
  • 100
  • 184 a.a.
Protein Preferred Names Protein Names

glucosamine 6-phosphate N-acetyltransferase

  • phosphoglucosamine acetylase

GNPNAT1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GNPNAT1 Q96EK6 MSRB2 Homo sapiens Q9Y3D2
Anti Tag CoIP
33961781
Intra
GNPNAT1 Q96EK6 C1QA Homo sapiens P02745
Y2H Array
21988832
Intra
GNPNAT1 Q96EK6 NAGK Homo sapiens Q9UJ70
Y2H Array
21988832
Intra
GNPNAT1 Q96EK6 GNPNAT1 Homo sapiens Q96EK6
Y2H Array
25416956
Intra
GNPNAT1 Q96EK6 GNPNAT1 Homo sapiens Q96EK6
X-Ray Diffraction
18675810
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Rhizomelic Dysplasia, Ain-Naz Type

  • RHZDAN
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05573 GNPNAT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20210 Gnpnat1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26715 Gnpnat1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GNPNAT1 MGD MGI:1858963
Macaca mulatta GNPNAT1 VGNC VGNC:72971
Canis familiaris GNPNAT1 VGNC VGNC:41333
Felis catus GNPNAT1 VGNC VGNC:62632
Bos taurus GNPNAT1 VGNC VGNC:29478
Rattus norvegicus GNPNAT1 RGD RGD:1563144
Others GNPNAT1 NCBI