papain (USP)
Based on 1 Customer Validation
Papain (USP) refers to Papain (HY-P1645) that meets the standards of the US Pharmacopoeia. Papain is a cysteine protease of the peptidase C1 family. Papain enhances red cell agglutination by anti-D and anti-A, and increases red cell sensitivity to K cell-mediated lysis in ADCC assays. Papain can induce pulmonary emphysema. Papain can be used for the researches of Rh haemolytic disease of the newborn and pulmonary emphysema.
For research use only. We do not sell to patients.
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Papain (5 U/mL; 15 min) pretreatment of O Rh-positive red cells enhances anti-D-mediated agglutination, while it slightly reduces anti-A-mediated agglutination of A Rh-negative red cells[2].
Papain (5 U/mL; 15 min) pretreatment of O Rh-positive red cells increases their sensitivity to lymphocyte-mediated lysis in anti-D-mediated ADCC assays at low antibody concentrations and a 15:1 effector-to-target ratio[2].
Papain (5 U/mL; 15 min) pretreatment of O Rh-positive target red cells enables significant PBMC-mediated lysis in anti-D-mediated ADCC assays at a 1:3:3 effector-to-target-to-competitor ratio[2].
Papain (5 U/mL; 15 min) pretreatment of A Rh-negative target red cells enables significant PBMC-mediated lysis in anti-A-mediated ADCC assays at a 1:3:3 effector-to-target-to-competitor ratio[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Color White to off-white
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SMILES
[papain (USP)]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (266 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Machado MN, et al. Bone Marrow-Derived Mononuclear Cell Therapy in Papain-Induced Experimental Pulmonary Emphysema. Front Physiol. 2018;9:121. Published 2018 Feb 20. [Content Brief]
[2]. Kumpel BM, et al. Comparison of lysis of bromelain and papain treated red cells in ADCC assays. Immunol Lett. 1992;31(3):237-240. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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