2-Thiocytidine
Based on 1 Customer Validation
2-Thiocytidine is a natural thionucleoside in prokaryotic tRNA, which is biosynthesized under the catalysis of intracellular sulfur transferase systems and possesses multiple activities such as metal coordination and nucleic acid conformation regulation. 2-Thiocytidine forms stable Zn2+ and Cd2+ complexes via its (C2) S group, with partial involvement of N3; metal binding acidifies the deprotonation process of (C4) NH2. 2-Thiocytidine can be used in related research in various fields including nanotechnology and click chemistry for interstrand DNA crosslinking.
For research use only. We do not sell to patients.
- Purity: 99.23%
- CAS No.: 13239-97-9
- Formula: C9H13N3O4S
- Molecular Weight:259.28
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Biological Activity
2-Thiocytidine (C2S) has a pKa value of 3.44 in aqueous solution and exhibits stronger acidity than monoprotonated cytidine; deprotonation of this molecule occurs in water with a corresponding pKa of 12.65[1].
2-Thiocytidine (0.4 mM) forms Zn (C2S)2+ and Zn (C2S-H)+ complexes in aqueous solution, where the (C2) S serves as the primary binding site for Zn2+[1].
2-Thiocytidine (0.4 mM) forms Cd (C2S)2+ and Cd (C2S-H)+ complexes in aqueous solution, where (C2) S serves as the primary binding site for Cd2+[1].
2-Thiocytidine can be efficiently incorporated into a DY647-labeled, triple-modified 17-mer RNA sequence via solid-phase phosphoramidite synthesis[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 13239-97-9
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Appearance Solid
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Molecular Weight 259.28
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Formula C9H13N3O4S
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Color White to off-white
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SMILES
S=C1N([C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)C=CC(N)=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 125 mg/mL (482.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8568 mL | 19.2842 mL | 38.5683 mL | 96.4209 mL |
| 5 mM | 0.7714 mL | 3.8568 mL | 7.7137 mL | 19.2842 mL | |
| 10 mM | 0.3857 mL | 1.9284 mL | 3.8568 mL | 9.6421 mL | |
| 15 mM | 0.2571 mL | 1.2856 mL | 2.5712 mL | 6.4281 mL | |
| 20 mM | 0.1928 mL | 0.9642 mL | 1.9284 mL | 4.8210 mL | |
| 25 mM | 0.1543 mL | 0.7714 mL | 1.5427 mL | 3.8568 mL | |
| 30 mM | 0.1286 mL | 0.6428 mL | 1.2856 mL | 3.2140 mL | |
| 40 mM | 0.0964 mL | 0.4821 mL | 0.9642 mL | 2.4105 mL | |
| 50 mM | 0.0771 mL | 0.3857 mL | 0.7714 mL | 1.9284 mL | |
| 60 mM | 0.0643 mL | 0.3214 mL | 0.6428 mL | 1.6070 mL | |
| 80 mM | 0.0482 mL | 0.2411 mL | 0.4821 mL | 1.2053 mL | |
| 100 mM | 0.0386 mL | 0.1928 mL | 0.3857 mL | 0.9642 mL |
2-Thiocytidine Related Classifications
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