Demethylcarolignan E
Demethylcarolignan E is a phenylpropanoid ester that can be isolated from the stems of Hibiscus taiwanensi. Demethylcarolignan E has cytotoxicity against human cancer lines A549 and MCF-7 (IC50: <10 μg/mL).
For research use only. We do not sell to patients.
- CAS No.: 873694-46-3
- Formula: C39H40O13
- Molecular Weight:716.73
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| DLD-1 | IC50 |
>40 μM
Compound: 2
|
Cytotoxicity against human Wnt-dependent DLD1 cells after 24 hrs by fluorometric microculture cytotoxicity assay
Cytotoxicity against human Wnt-dependent DLD1 cells after 24 hrs by fluorometric microculture cytotoxicity assay
|
[PMID: 26026364] |
| HCT-116 | IC50 |
>39 μM
Compound: 2
|
Cytotoxicity against human Wnt-dependent HCT116 cells after 24 hrs by fluorometric microculture cytotoxicity assay
Cytotoxicity against human Wnt-dependent HCT116 cells after 24 hrs by fluorometric microculture cytotoxicity assay
|
[PMID: 26026364] |
| HEK293 | IC50 |
24.2 μM
Compound: 2
|
Cytotoxicity against human HEK293 cells after 24 hrs by fluorometric microculture cytotoxicity assay
Cytotoxicity against human HEK293 cells after 24 hrs by fluorometric microculture cytotoxicity assay
|
[PMID: 26026364] |
| HEK293 | IC50 |
4.5 μM
Compound: 2
|
Inhibition of Wnt/beta-catenin signaling in HEK293 cells stably transfected with TOP reporter gene assessed as TCF/beta-catenin transcriptional activity after 24 hrs by TOP activity/luciferase reporter gene assay
Inhibition of Wnt/beta-catenin signaling in HEK293 cells stably transfected with TOP reporter gene assessed as TCF/beta-catenin transcriptional activity after 24 hrs by TOP activity/luciferase reporter gene assay
|
[PMID: 26026364] |
| RKO | IC50 |
23 μM
Compound: 2
|
Cytotoxicity against human Wnt-independent RKO cells after 24 hrs by fluorometric microculture cytotoxicity assay
Cytotoxicity against human Wnt-independent RKO cells after 24 hrs by fluorometric microculture cytotoxicity assay
|
[PMID: 26026364] |
| SW480 | IC50 |
>40 μM
Compound: 2
|
Cytotoxicity against human Wnt-dependent SW480 cells after 24 hrs by fluorometric microculture cytotoxicity assay
Cytotoxicity against human Wnt-dependent SW480 cells after 24 hrs by fluorometric microculture cytotoxicity assay
|
[PMID: 26026364] |
Chemical Information
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CAS No. 873694-46-3
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Molecular Weight 716.73
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Formula C39H40O13
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SMILES
O=C(OC[C@H](OC1=CC=C(CCCOC(/C=C/C2=CC=C(O)C(OC)=C2)=O)C=C1O)[C@@H](O)C3=CC=C(O)C(OC)=C3)/C=C/C4=CC=C(O)C(OC)=C4
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Synonyms
Carolignan M
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)