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Cat. No.: HY-N19297

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Endosidin1

(Synonyms: Prieurianin)

Endosidin1 (Prieurianin) is a Prieurianin with cleaved A and B rings. Endosidin1 is isolated from the roots of Aphanamixis polystachya. Endosidin1 inhibits superoxide anion production and Elastase release in neutrophils, with an IC₅₀ >10 μg/mL. Endosidin1 exhibits mild cytotoxic activity against laryngeal cancer cells in vitro. Endosidin1 shows anti-inflammatory activity. Endosidin1 can be used in studies related to laryngeal cancer.\n

For research use only. We do not sell to patients.

CAS No.: 57672-91-0
Formula: C₃₈H₅₀O₁₆
Molecular Weight:762.79

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Endosidin1 Chemical Structure

CAS No.: 57672-91-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Bioz

Biological Activity

Description

In Vitro

Endosidin1 (3 days) exhibits mild cytotoxicity against HEp-2 laryngeal cancer cells with an ED₅₀ of 16.77 μg/mL, but shows no significant cytotoxicity against Hep-G2, A549 or MCF-7 cells^[1].
Endosidin1 inhibits superoxide anion production in FMLP/CB-stimulated neutrophils by 49.20%, with an IC₅₀ >10 μg/mL^[1].
Endosidin1 (10 μg/mL) inhibits elastase release from neutrophils stimulated by FMLP/CB, with an inhibition rate of 39.36% at the concentration of 10 μg/mL and an IC₅₀ >10 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

human HEp-2 (laryngeal carcinoma) cells, Hep-G2 cells, A549 cells, MCF-7 cells
Concentration:

16.77 μg/mL (HEp-2 ED₅₀); >40 μg/mL (Hep-G2, A549, MCF-7 ED₅₀)
Incubation Time:

3 days
Result:

Showed mild cytotoxic activity against HEp-2 cells, with an IC₅₀ value of 16.77 μg/mL.
Exhibited no significant cytotoxicity against Hep-G2, A549, or MCF-7 cells (ED₅₀ >40 μg/mL for all three cell lines).

Chemical Information

CAS No. 57672-91-0
Molecular Weight 762.79
Formula C₃₈H₅₀O₁₆
SMILES

C[C@@]12[C@H]([C@@H]([C@@]([C@@]3([C@H]([C@](C)(OC(C[C@@H]3OC(C)=O)=O)COC(C)=O)CC(OC)=O)C)([H])C([C@]1(C(C[C@H]2C4=COC=C4)=O)O)=C)OC=O)OC([C@H](O)[C@H](C)CC)=O
Synonyms

Prieurianin
Structure Classification
- Others
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lin CJ, et al. Tetranortriterpenes and Limonoids from the Roots of Aphanamixis polystachya. Molecules. 2016;21(9):1167. Published 2016 Sep 2. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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