country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-180145

Copy Link Print Information

Furin-IN-3

Furin-IN-3 is a non-peptidic furin inhibitor with a dichlorobiphenyl-derived core, with a K_i value of 1.67 nM for furin inhibition and a K_i value of 278 nM for proprotein convertase PC7 inhibition. Furin-IN-3 can be used in the research of influenza A virus infection (H7N7 strain SC35M).

For research use only. We do not sell to patients.

CAS No.: 3080672-14-3
Formula: C₃₈H₄₇Cl₂F₉N₄O₇
Molecular Weight:913.69

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Furin-IN-3 Chemical Structure

CAS No.: 3080672-14-3

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

furin

1.67 nM (Ki)

PC7

278 nM (Ki)

In Vitro

Furin-IN-3 (compound 9) inhibits furin with a K_ivalue of 12.4 nM in a fluorogenic substrate assay, indicating that it ranks among the moderately potent inhibitors in this series [1].
Furin-IN-3 inhibits PC7 with a K_i value of 278 nM, indicating that it exhibits significantly weaker activity against this related proprotein convertase than against furin^[1].
Furin-IN-3 (72 h) demonstrates the most potent antiviral activity against the H7N7 influenza strain SC35M in A549 cells at 5 μM, reducing viral titers by 10⁴ to 10⁵-fold^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3080672-14-3
Molecular Weight 913.69
Formula C₃₈H₄₇Cl₂F₉N₄O₇
SMILES

O=C(C(F)(F)F)O.O=C(C)NCC1CCN(CC1)CC2=CC(C3=CC(Cl)=CC(Cl)=C3)=CC(CN4CCC(C5CCNCC5)CC4)=C2.O=C(C(F)(F)F)O.O=C(C(F)(F)F)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lange RW, et al. Design, Synthesis, and Characterization of Dichlorobiphenyl-Derived Inhibitors of the Proprotein Convertase Furin. Journal of medicinal chemistry. 2025 Dec 11;68(23):25157-25170. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote