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NFKBIB - NFKB inhibitor beta Gene

Also Known as IKBB; TRIP9

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4793

About NFKBIB

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:38,899,666-38,908,889 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 125 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 8.2), bone marrow (RPKM 7.5) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011]

NFKBIB Products (4)

mRNA	Protein	Name
NM_001243116.2	NP_001230045.1	NF-kappa-B inhibitor beta isoform 2
NM_001369699.1	NP_001356628.1	NF-kappa-B inhibitor beta isoform 3
NM_001369700.1	NP_001356629.1	NF-kappa-B inhibitor beta isoform 4
NM_002503.5	NP_002494.2	NF-kappa-B inhibitor beta isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10498867	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NFKBIB Protein Structure

Ank_2

0
100
200
300
356 a.a.

Protein Preferred Names	Protein Names
NF-kappa-B inhibitor beta	I-kappa-B-beta

NFKBIB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NFKBIB	Q15653	BTBD6	Homo sapiens	Q96KE9-2	Y2H Prey Pooling	32296183
Intra	NFKBIB	Q15653	BTBD6	Homo sapiens	Q96KE9-2	Validated Y2H	32296183
Intra	NFKBIB	Q15653	BTBD6	Homo sapiens	Q96KE9-2	Y2H Array	32296183
Intra	NFKBIB	Q15653	NDUFB7	Homo sapiens	P17568	Y2H Array	32296183
Intra	NFKBIB	Q15653	NDUFB7	Homo sapiens	P17568	Y2H Prey Pooling	32296183
Intra	NFKBIB	Q15653	VPS52	Homo sapiens	Q8N1B4	Y2H Prey Pooling	25416956
Intra	NFKBIB	Q15653	NFKB1	Homo sapiens	P19838	Anti Tag CoIP	33961781
Intra	NFKBIB	Q15653	NFKB2	Homo sapiens	Q00653	Anti Tag CoIP	33961781
Intra	NFKBIB	Q15653	NFKB2	Homo sapiens	Q00653	TAP	14743216
Intra	NFKBIB	Q15653	REL	Homo sapiens	Q04864	TAP	14743216
Intra	NFKBIB	Q15653	REL	Homo sapiens	Q04864	Anti Tag CoIP	33961781
Intra	NFKBIB	Q15653	NFKBIA	Homo sapiens	P25963	TAP	14743216
Intra	NFKBIB	Q15653	MCC	Homo sapiens	P23508	Anti Tag CoIP	33961781
Intra	NFKBIB	Q15653	MCC	Homo sapiens	P23508	Anti Tag CoIP	14743216
Intra	NFKBIB	Q15653	RASAL2	Homo sapiens	Q9UJF2	Anti Tag CoIP	33961781
Intra	NFKBIB	Q15653	POLR1E	Homo sapiens	Q9GZS1	Anti Tag CoIP	33961781
Intra	NFKBIB	Q15653	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	NFKBIB	Q15653	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	NFKBIB	Q15653	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	NFKBIB	Q15653	RELA	Homo sapiens	Q04206	Anti Tag CoIP	33961781
Intra	NFKBIB	Q15653	RELA	Homo sapiens	Q04206	Y2H	10498867
Intra	NFKBIB	Q15653	RELA	Homo sapiens	Q04206	Y2H Array	21988832
Intra	NFKBIB	Q15653	CHUK	Homo sapiens	O15111	TAP	14743216
Intra	NFKBIB	Q15653	CHUK	Homo sapiens	O15111	Anti Tag CoIP	33961781
Intra	NFKBIB	Q15653	IKBKB	Homo sapiens	O14920	Anti Tag CoIP	33961781
Intra	NFKBIB	Q15653	IKBKG	Homo sapiens	Q9Y6K9	Anti Tag CoIP	33961781
Cross	NFKBIB	Q15653	polg_den2n	Dengue virus type 2	P14340	Anti Tag CoIP	24973451

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NFKBIB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76986	IKB beta/NFKBIB Protein, Human (His)	Q15653-1/NP_002494.2 (M1-V356)	≥ 95%, as determined by reducing SDS-PAGE.

NFKBIB Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83343	IKB beta Antibody (YA3088)	WB, IHC-P, ICC/IF, FC, IP	Human
HY-P83343A	IKB beta Antibody (YA3088)(PBS only)	WB, IHC-P, ICC/IF, FC, IP	Human
HY-P84592	IKB beta Antibody (YA4289)	WB, ELISA	Human
HY-P84592A	IKB beta Antibody (YA4289)(PBS only)	WB, ELISA	Human
HY-P85710	IKB beta Antibody (YA5402)	IHC-P, WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Ectodermal Dysplasia 10a, Hypohidrotic/Hair/Nail Type, Autosomal Dominant	ECTD10A Hed Ectodermal Dysplasia 10a Ectodermal Dysplasia Hypohidrotic Autosomal Dominant Autosomal Dominant Hypohidrotic Ectodermal Dysplasia Ectodermal Dysplasia, Hypohidrotic, Autosomal Dominant Hypohidrotic Ectodermal Dysplasia Autosomal Dominant Ad-Hed Autosomal Dominant Anhidrotic Ectodermal Dysplasia Ectodermal Dysplasia 3 Ed3 Eda3 Ectodermal Dysplasia, Anhidrotic, Autosomal Dominant Dysplasia, Ectodermal, Type 10a, Hypohidrotic/Hair/Nail, Autosomal Dominant Dysplasia, Ectodermal, Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09261	NFKBIB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20185	Nfkbib Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26689	Nfkbib Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NFKBIB	MGD	MGI:104752
Felis catus	NFKBIB	VGNC	VGNC:68484
Macaca mulatta	NFKBIB	VGNC	VGNC:75341
Bos taurus	NFKBIB	VGNC	VGNC:32046
Rattus norvegicus	NFKBIB	RGD	RGD:621887
Canis familiaris	NFKBIB	VGNC	VGNC:43783
Others	NFKBIB	NCBI