IKB beta Antibody (YA4289)
(Synonyms: IKBB; TRIP9; NFKBIB)IKB beta Antibody (YA4289) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IKB beta.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, ELISA
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Reactivity :
Human
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Formulation:
Supplied in ascitic fluid containing 0.03% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:10000 |
Product Details
IKB beta Antibody (YA4289) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IKB beta.
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Host Mouse
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 48 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 38 kDa
Purified recombinant fragment of human NFKBIB aa 124-356.
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in ascitic fluid containing 0.03% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
IKB beta inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation
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Subcellular Localization
Cytoplasm; Nucleus
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Expression
Tissue_specificity:It was expressed in all the tissues tested. -
Isoforms & Post-Translational Modification
Q15653 has 2 isomers: Q15653-1: 37771 Da (predicted); Q15653-2: 35530 Da (predicted).
Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation -
Subunit
Interacts with THRB (via ligand-binding domain) (PubMed:7776974). Interacts with RELA and REL (By similarity). Interacts with COMMD1 (PubMed:16573520).
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SwissProt ID
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Synonyms
IKBB; TRIP9; NFKBIB
Documentation
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