IKB beta Antibody (YA5402)
(Synonyms: NF-kappa-B inhibitor beta; NF-kappa-BIB; I-kappa-B-beta; IkB-B; IkB-beta; IkappaBbeta; Thyroid receptor-interacting protein 9; TR-interacting protein 9; TRIP-9; )IKB beta Antibody (YA5402) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to IKB beta.
-
Host:
Mouse
-
Application:
IHC-P, WB
-
Reactivity :
Human, Mouse, Rat
-
Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC1
|
WB
WB: Western Blot
|
|---|---|---|
| Dilution Ratio | 50-200 | 1:1000-2000 |
Product Details
IKB beta Antibody (YA5402) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to IKB beta.
-
Host Mouse
-
Clonality Monoclonal
-
Species ReactivityHuman, Mouse, Rat
-
Observed Molecular WeightObserved band size: 45-48 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Synthesized peptide derived from human IκB β
affinity chromatography.
Non-conjugated
Unmodified
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
IKB beta inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation
-
Subcellular Localization
Cytoplasm; Nucleus
-
Expression
Tissue_specificity:It was expressed in all the tissues tested. -
Isoforms & Post-Translational Modification
Q15653 has 2 isomers: Q15653-1: 37771 Da (predicted); Q15653-2: 35530 Da (predicted).
Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation -
Subunit
Interacts with THRB (via ligand-binding domain) (PubMed:7776974). Interacts with RELA and REL (By similarity). Interacts with COMMD1 (PubMed:16573520).
-
SwissProt ID
-
Synonyms
NF-kappa-B inhibitor beta; NF-kappa-BIB; I-kappa-B-beta; IkB-B; IkB-beta; IkappaBbeta; Thyroid receptor-interacting protein 9; TR-interacting protein 9; TRIP-9;
Documentation
Powered by Bioz
