Uchl3 - ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 50933

Summary

Enables Deubiquitinase activity. Involved in cellular response to Insulin stimulus; positive regulation of fat cell differentiation; and protein catabolic process. Acts upstream of or within several processes, including adult walking behavior; eating behavior; and protein deubiquitination. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including embryo ectoderm; genitourinary system; gut; hemolymphoid system gland; and liver. Orthologous to human UCHL3 (ubiquitin C-terminal hydrolase L3). [provided by Alliance of Genome Resources, Apr 2022]

Uchl3 Products (1)

mRNA Protein Name
NM_016723.2 NP_057932.2 ubiquitin carboxyl-terminal hydrolase isozyme L3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables deubiquitinase activity IDA
IDA: Inferred from direct assay
26609154 MGI
enables peptidase activity IDA
IDA: Inferred from direct assay
21762696 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adult walking behavior IGI
IGI: Inferred from genetic interaction
11555633 MGI
involved in cellular response to insulin stimulus IDA
IDA: Inferred from direct assay
19837878 MGI
acts upstream of or within eating behavior IGI
IGI: Inferred from genetic interaction
11555633 MGI
involved in positive regulation of fat cell differentiation IDA
IDA: Inferred from direct assay
19837878 MGI
involved in protein catabolic process IDA
IDA: Inferred from direct assay
21762696 MGI
acts upstream of or within protein deubiquitination IDA
IDA: Inferred from direct assay
26609154 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: Inferred from mutant phenotype
21052544 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase isozyme L3

  • UCH-L3

  • ubiquitin thioesterase L3

  • ubiquitin thiolesterase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18637 LDN-57444 99.21% Unkown
HY-18638 TCID Inhibitor 99.78% Unkown
HY-133118 6RK73 Inhibitor 98.41% Unkown
HY-149230 USP28-IN-4 Inhibitor 98.86% Unkown
HY-149229 USP28-IN-3 Inhibitor 98.26% Unkown
HY-149228 USP28-IN-2 Inhibitor / Unkown
HY-182636 MT16-001 Inhibitor / Unkown
HY-RS15401 UCHL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17309 Uchl3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23764 Uchl3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Uchl3 NCBI NCBI:7347