2. Cell Cycle/DNA Damage
  3. Deubiquitinase
  4. TCID

TCID  (Synonyms: 4,5,6,7-Tetrachloroindan-1,3-dione)

Cat. No.: HY-18638 Purity: 99.87%
COA Handling Instructions

TCID (4,5,6,7-Tetrachloroindan-1,3-dione) is a potent and selective neuronal ubiquitin C-terminal hydrolase (UCH-L3) inhibitor with an IC50 of 0.6 μM. TCID diminishes glycine transporter GlyT2 ubiquitination in brainstem and spinal cord primary neurons.

For research use only. We do not sell to patients.

TCID Chemical Structure

TCID Chemical Structure

CAS No. : 30675-13-9

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 94 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 94 In-stock
Solid
1 mg USD 30 In-stock
5 mg USD 65 In-stock
10 mg USD 103 In-stock
25 mg USD 237 In-stock
50 mg   Get quote  
100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

TCID Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE TCID

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

TCID (4,5,6,7-Tetrachloroindan-1,3-dione) is a potent and selective neuronal ubiquitin C-terminal hydrolase (UCH-L3) inhibitor with an IC50 of 0.6 μM[1]. TCID diminishes glycine transporter GlyT2 ubiquitination in brainstem and spinal cord primary neurons[2].

IC50 & Target

IC50: 0.6 μM (UCH-L3) and 75 μM (UCH-L1)[1]
In Vitro

TCID (4,5,6,7-Tetrachloroindan-1,3-dione; compound 11) inhibits UCH-L1 with an IC50 of 75 μM[1].
TCID (10 μM; 1, 2 hours) diminishes glycine transporter GlyT2 ubiquitination in brainstem and spinal cord primary neurons[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TCID Related Antibodies
Molecular Weight

283.92

Appearance

Solid

Formula

C9H2Cl4O2
CAS No.
SMILES

O=C1CC(C2=C1C(Cl)=C(Cl)C(Cl)=C2Cl)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (146.77 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5221 mL 17.6106 mL 35.2212 mL
5 mM 0.7044 mL 3.5221 mL 7.0442 mL
10 mM 0.3522 mL 1.7611 mL 3.5221 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.33 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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TCID Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

TCID30675-13-94,5,6,7-Tetrachloroindan-1,3-dioneDeubiquitinaseDUBsNeuronalubiquitinC-terminalhydrolaseUCH-L3UCH-L1glycinetransporterGlyT2ubiquitinationInhibitorinhibitorinhibit

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