30675-13-9
30675-13-9
Chemical Structure
TCID
Synonym(s): 4,5,6,7-Tetrachloroindan-1,3-dione
- CAS No.: 30675-13-9
- Formula:C9H2Cl4O2
- Molecular Weight:283.92
IUPAC Name: 4,5,6,7-tetrachloro-1H-indene-1,3(2H)-dione
InChIKey: IDLAOWFFKWRNHB-UHFFFAOYSA-N
SMILES: O=C1CC(C2=C1C(Cl)=C(Cl)C(Cl)=C2Cl)=O
Biological Activity: TCID (4,5,6,7-Tetrachloroindan-1,3-dione) is a potent and selective neuronal ubiquitin C-terminal hydrolase (UCH-L3) inhibitor with an IC50 of 0.6 μM[1]. TCID diminishes glycine transporter GlyT2 ubiquitination in brainstem and spinal cord primary neurons[2].
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TCID | 99.78% | TCID (4,5,6,7-Tetrachloroindan-1,3-dione) is a potent and selective neuronal ubiquitin C-terminal hydrolase (UCH-L3) inhibitor with an IC50 of 0.6 μM. TCID diminishes glycine transporter GlyT2 ubiquitination in brainstem and spinal cord primary neurons. | ||||||||||||||||||||
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References
- [1]. Liu Y, et al. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cellline. Chem Biol. 2003 Sep;10(9):837-46. [Content Brief]
- [2]. de Juan-Sanz J, et al. Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster. PLoS One. 2013;8(3):e58863. [Content Brief]
Keywords
