NCOA4 - nuclear receptor coactivator 4 Gene

Also Known as RFG; ELE1; PTC3; ARA70

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8031

About NCOA4

Cytogenetic location: 10q11.22 Genomic coordinates (GRCh38): 10:46,005,088-46,030,623 (from NCBI)

This gene has 7 transcripts (splice variants), 216 orthologues and is associated with 17 phenotypes. Ubiquitous expression in duodenum (RPKM 113.8), liver (RPKM 75.2) and 25 other tissues.

Summary

This gene encodes an Androgen Receptor coactivator. The encoded protein interacts with the Androgen Receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the RET tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009]

NCOA4 Products (5)

mRNA	Protein	Name
NM_001145260.2	NP_001138732.1	nuclear receptor coactivator 4 isoform 1
NM_001145261.2	NP_001138733.1	nuclear receptor coactivator 4 isoform 2
NM_001145262.2	NP_001138734.1	nuclear receptor coactivator 4 isoform 3
NM_001145263.2	NP_001138735.1	nuclear receptor coactivator 4 isoform 3
NM_005437.4	NP_005428.1	nuclear receptor coactivator 4 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within protein targeting to lysosome	IDA IDA: Inferred from direct assay	25327288	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in autolysosome	IDA IDA: Inferred from direct assay	25327288	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCOA4 Protein Structure

ARA70

0
100
200
300
400
500
614 a.a.

Protein Preferred Names	Protein Names
nuclear receptor coactivator 4	70 kDa AR-activator

NCOA4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NCOA4	Q13772	FTL	Homo sapiens	P02792	Anti Tag CoIP	33961781
Intra	NCOA4	Q13772	FTL	Homo sapiens	P02792	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

NCOA4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84934	NCOA4 Antibody (YA4630)	WB	Human
HY-P84935	NCOA4 Antibody (YA4631)	IHC-P, IF-Tissue	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Differentiated Thyroid Carcinoma	Papillary Or Follicular Thyroid Carcinoma Well-Differentiated Thyroid Carcinoma Differentiated Thyroid Gland Carcinoma
Withdrawal Disorder	Withdrawal Syndrome Substance Withdrawal Syndrome
Papillary Carcinoma	Carcinoma, Papillary Carcinoma Papillary
Hashimoto Thyroiditis	Autoimmune Thyroiditis Hashimoto Struma Hashimoto'S Thyroiditis Chronic Lymphocytic Thyroiditis Lymphocytic Thyroiditis Hashimoto Disease Ht Hashimoto'S Disease Hashimoto'S Syndrome Hypothyroidism, Autoimmune Autoimmune Chronic Lymphocytic Thyroiditis Chronic Lymphocytic Thyroiditides Hashimoto Syndrome Hashimotos Thyroiditis Hashimoto Thyroiditis, Susceptibility To Thyroiditis, Autoimmune Lymphomatous Thyroiditis Lymphoid Thyroiditis Chronic Lymphadenoid Thyroiditis Autoimmune Lymphocytic Chronic Thyroiditis Goitre Lymphomatosa Hashitoxicosis Hashimoto Hypothyroidism Lymphadenoid Goitre Struma Lymphomatosa Hyperthyroidism With Hashimoto Disease Hashimoto Thyrotoxicosis Thyrotoxicosis Due To Hashimoto Thyroiditis Struma Lymphomatosis Lymphadenoid Struma
Thyroid Gland Cancer	Thyroid Gland Carcinoma Malignant Neoplasm Of Thyroid Gland Malignant Tumour Of Thyroid Gland Thyroid Neoplasm Thyroid Neoplasms Neoplasm Of Thyroid Gland Thyroid Gland Neoplasm Head And Neck Cancer, Thyroid Neoplasm Of The Thyroid Gland Cancer Of The Thyroid Primary Malignant Neoplasm Of Thyroglossal Duct Malignant Neoplasm Of Thyroglossal Duct Primary Malignant Neoplasm Of Thyroid Gland Thyroglossal Duct Cancer Toxic Goitre Malignant Tumour Cancerous Goitre
Benign Struma Ovarii
Multiple Endocrine Neoplasia, Type Iib	Multiple Endocrine Neoplasia Type 2b MEN2B Wagenmann-Froboese Syndrome Multiple Endocrine Neoplasia Iib Mucosal Neuroma Syndrome Multiple Endocrine Neoplasia, Type 3 Multiple Endocrine Neoplasia, Type 2b Men Iib Neuromata, Mucosal, With Endocrine Tumors Multiple Endocrine Neoplasia, Type Iii, Formerly Men3, Formerly Men Type Iib Men 2b Multiple Endocrine Neoplasia Type 3 Multiple Neoplasia 2b Neoplasia, Endocrine, Multiple, Type Iib
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Ovarian Germ Cell Teratoma	Germ Cell Teratoma Of Ovary Ovarian Teratoma
Thyroid Gland Follicular Carcinoma	Follicular Thyroid Carcinoma Follicular Adenocarcinoma Follicular Adenocarcinoma, Well Differentiated Follicular Carcinoma Thyroid Adenocarcinoma Adenocarcinoma, Follicular
Struma Ovarii
Thyroid Gland Medullary Carcinoma	Medullary Thyroid Carcinoma Medullary Carcinoma Of The Thyroid Gland Ultimobranchial Thyroid Tumor Ultimobranchial Thyroid Tumour Thyroid Cancer, Medullary
Malignant Struma Ovarii	Struma Ovarii, Malignant
Multinodular Goiter
Thyroid Gland Anaplastic Carcinoma	Anaplastic Thyroid Carcinoma Anaplastic Thyroid Cancer Thyroid Cancer, Anaplastic Thyroid Carcinoma, Anaplastic Thyroid Carcinoma Anaplastic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N9362	Emodinanthrone	Inhibitor	98.66%	Unkown
HY-163897	PROTAC NCOA4 degrader-1	Inhibitor	99.75%	Unkown
HY-N8210	Homoeriodictyol		99.86%	Unkown
HY-N5008	Macranthoside B		99.95%	Unkown
HY-175869	Ferroptosis-IN-22	Inhibitor	99.97%	Unkown
HY-RS09092	NCOA4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-173119	SKLB-D18		98.06%	Unkown
HY-138678B	(S,R,R)-VH032		/	Unkown
HY-163904	(S,R,R)-VH032-CO-C3-CONH-C2-PEG3-OH		/	Unkown
HY-N9362R	Emodinanthrone (Standard)	Inhibitor	/	Unkown
HY-RS16942	Ncoa4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23385	Ncoa4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NCOA4	VGNC	VGNC:68433
Rattus norvegicus	NCOA4	RGD	RGD:1563014
Mus musculus	NCOA4	MGD	MGI:1350932
Macaca mulatta	NCOA4	VGNC	VGNC:97794
Canis familiaris	NCOA4	VGNC	VGNC:43661
Bos taurus	NCOA4	VGNC	VGNC:31922
Others	NCOA4	NCBI