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Cat. No.: HY-106920

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Kynostatin 272

(Synonyms: KNI 272; Kynostatin; NSC 651714)

Kynostatin 272 (KNI 272) is a potent HIV protease inhibitor. Kynostatin 272 inhibits the activity of the HIV protease by simulating the substrate transition state of the HIV protease, thus preventing a key step in the replication of the HIV virus. Kynostatin 272 provides an important research foundation for the development of drugs for HIV and AIDS.

For research use only. We do not sell to patients.

CAS No.: 147318-81-8
Formula: C₃₃H₄₁N₅O₆S₂
Molecular Weight:667.84

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Kynostatin 272 Chemical Structure

CAS No.: 147318-81-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
CEM-SS	EC₅₀	40 nM Compound: KNI-272	Inhibitory activity against HIV-1 IIIB in CEM-SS infected cells Inhibitory activity against HIV-1 IIIB in CEM-SS infected cells	[PMID: 10206539]
H9	EC₅₀	0.02 μM Compound: KNI-272	Antiviral activity against HIV1 RF in human H9 cells assessed as inhibition of virus-induced cytopathic effect by formazan-based conventional colorimetric technique Antiviral activity against HIV1 RF in human H9 cells assessed as inhibition of virus-induced cytopathic effect by formazan-based conventional colorimetric technique	[PMID: 11430019]
MT4	EC₅₀	0.57 nM Compound: KNI-272	Inhibitory activity against HIV-1 IIIB in MT-4 infected cells Inhibitory activity against HIV-1 IIIB in MT-4 infected cells	[PMID: 10206539]
MT4	EC₅₀	22 nM Compound: 1, KNI-272	Antiviral activity against HIV1 3B in MT4 cells by MTT assay Antiviral activity against HIV1 3B in MT4 cells by MTT assay	[PMID: 17537628]
MT4	EC₅₀	22 nM Compound: 1	Antiviral activity against HIV1 3B in human MT4 cells assessed as inhibition of viral-induced cytopathic effect by MTT method Antiviral activity against HIV1 3B in human MT4 cells assessed as inhibition of viral-induced cytopathic effect by MTT method	[PMID: 18426195]
MT4	CC₅₀	>30000 nM Compound: 1	Cytotoxicity against human MT4 cells by MTT assay Cytotoxicity against human MT4 cells by MTT assay	[PMID: 18426195]

Chemical Information

CAS No. 147318-81-8
Molecular Weight 667.84
Formula C₃₃H₄₁N₅O₆S₂
SMILES

O=C(N1[C@@H](CSC1)C(NC(C)(C)C)=O)[C@@H](O)[C@H](CC2=CC=CC=C2)NC([C@H](CSC)NC(COC3=C4C(C=NC=C4)=CC=C3)=O)=O
Synonyms

KNI 272; Kynostatin; NSC 651714
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kimura T, et al. Rigid backbone moiety of KNI-272, a highly selective HIV protease inhibitor: methanol, acetone and dimethylsulfoxide solvated forms of 3-[3-benzyl-2-hydroxy-9-(isoquinolin-5-yloxy)-6-methylsulfanylmethyl-5, 8-dioxo-4, 7-diazanonanoyl]-N-tert-butyl-1, 3-thiazolidine-4-carboxamide[J]. Acta Crystallographica Section B: Structural Science, 2004, 60(4): 433-437.

[2]. Freedberg D I, et al. Flexibility and function in HIV protease: Dynamics of the HIV-1 protease bound to the asymmetric inhibitor kynostatin 272 (KNI-272)[J]. Journal of the American Chemical Society, 1998, 120(31): 7916-7923.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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