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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
179 Results for "
lambda
" in MedChemExpress (MCE) Product Catalog:
Products (179)
179 Results for "lambda" in MCE Product Catalog:
Cat. No.: HY-P990932
CAS No.: 2851943-09-2
Synonyms: BI 764532; OBT 620
Cat. No.: HY-P99709
CAS No.: 2118349-31-6
Synonyms: LY3300054
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Cat. No.: HY-P990259
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Cat. No.: HY-P991461
Synonyms: XmAb968
Cat. No.: HY-133240
CAS No.: 1109241-72-6
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trans-AzoTAB is a photoresponsive potassium/sodium/calcium channel modulator and DNA-binding agent. trans-AzoTAB undergoes trans-cis isomerization driven by light, with variable polarity and DNA affinity. trans-AzoTAB also enhances voltage-gated potassium currents and inhibits sodium and calcium currents in cardiomyocytes, thereby reducing spontaneous electrical activity and excitation conduction velocity. In addition, trans-AzoTAB induces compaction and frozen conformation of λ-phage DNA, and non-sequence-dependently inhibits transcription and translation processes in the dark; its activity can be reversed and restored by visible light after activation with ultraviolet irradiation. trans-AzoTAB can serve as a probe for two-photon optical regulation of myocardial excitability, and is used to construct photoresponsive interfacial polymer structures .
Cat. No.: HY-P990281
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Cat. No.: HY-P990296
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Cat. No.: HY-P990301
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Cat. No.: HY-P990953
CAS No.: 2640279-10-1
Synonyms: Gen1047
Cat. No.: HY-P991381
Synonyms: PPMX-T003; TSP-A18
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Cat. No.: HY-P10667
Cat. No.: HY-N18124
CAS No.: 122688-84-0
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Cat. No.: HY-P991959
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Cat. No.: HY-P991402
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Cat. No.: HY-179413
CAS No.: 3050552-13-8
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Polθ-IN-9 is an orally active Polθ polymerase inhibitor (IC50 = 9.6 nM, Kd = 47.5 nM). Polθ-IN-9 shows remarkable selectivity with no inhibitory activity against other human DNA polymerases, including Pol α, Pol ε, Pol γ, Pol λ, and Pol μ. Polθ-IN-9 exhibits strong antiproliferative activity in DLD1 BRCA2 KO cells (IC50 = 2.9 μM), and high sensitivity to MDA-MB-436 cells (IC50 = 4.9 μM). Polθ-IN-9 increases DNA damage accumulation, induces γH2AX levels, and inhibits tumor growth in combination with Olaparib (HY-10162), in the MDA-MB-436 xenograft model. Polθ-IN-9 can be used for the research of homologous recombination (HR)-deficient cancers such as breast cancer .
Cat. No.: HY-P77390
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: IFNA14; Interferon Alpha-14; Interferon Alpha 14; Interferon Alpha-H; IFN-AlphaH; IFN-Alpha-14; LEIF2H; LeIF H; Interferon lambda-2-H; Interferon, Alpha 14
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Cat. No.: HY-W015490R
CAS No.: 130-15-4
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1,4-Naphthoquinone is an inhibitor with broad-spectrum inhibitory activity targeting DNA polymerase, NF-κB and monoamine oxidase (MAO-A/B), with antibacterial and anti-biofilm efficacy. 1,4-Naphthoquinone is a competitive inhibitor of MAO-B (Ki=1.4 μM) and a non-competitive inhibitor of MAO-A (Ki=7.7 μM). 1,4-Naphthoquinone inhibits DNA polymerase pol α, β, γ, δ, ε, λ with IC50 ranging from 5.57-128 μM. 1,4-Naphthoquinone inhibits tumor cell proliferation, induces apoptosis and necrosis, and has anti-angiogenic and anti-inflammatory activities by inducing oxidative stress, depleting glutathione (GSH), inhibiting DNA polymerase-mediated DNA synthesis and blocking NF-κB nuclear translocation. 1,4-Naphthoquinone can be used in anti-bacterial , anti-tumor and anti-inflammatory studies, including inhibition of melanoma and colon cancer cell growth and endothelial cell function, as well as LPS-induced inflammation models .
Cat. No.: HY-W015490S
CAS No.: 26473-08-5
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
