XF067-68
Based on 1 Customer Validation
XF067-68 (example 132) is a PROTAC for targeted degradation of WD40 repeat domain protein 5 (WDR5). XF067-68 can be usde for the study of WDR5-mediated diseases.
(Pink: WDR5 ligand (HY-141799); Blue: VHL ligand (HY-173627); Black: linker (HY-Y0966)).
For research use only. We do not sell to patients.
- Purity: 99.56%
- CAS No.: 2407452-79-1
- Formula: C52H59F4N9O7S
- Molecular Weight:1030.14
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Heterocyclic Compound Library
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PROTAC Library
HY-L151
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
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Posttranslational Modification Library
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All PROTACs Isoforms
More
Biological Activity
WDR5[1]
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2407452-79-1
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Appearance Solid
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Molecular Weight 1030.14
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Formula C52H59F4N9O7S
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Color White to off-white
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SMILES
O=C(C(C(C(F)(F)F)=C1)=CNC1=O)NC2=C(N3C[C@H](N([C@H](C3)C)C)C)C=CC(C4=CC(C(NCC(N[C@@H](C(C)(C)C)C(N5[C@H](C[C@@H](C5)O)C(N[C@H](C6=CC=C(C7=C(N=CS7)C)C=C6)C)=O)=O)=O)=O)=CC=C4F)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 100 mg/mL (97.07 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9707 mL | 4.8537 mL | 9.7074 mL | 24.2685 mL |
| 5 mM | 0.1941 mL | 0.9707 mL | 1.9415 mL | 4.8537 mL | |
| 10 mM | 0.0971 mL | 0.4854 mL | 0.9707 mL | 2.4269 mL | |
| 15 mM | 0.0647 mL | 0.3236 mL | 0.6472 mL | 1.6179 mL | |
| 20 mM | 0.0485 mL | 0.2427 mL | 0.4854 mL | 1.2134 mL | |
| 25 mM | 0.0388 mL | 0.1941 mL | 0.3883 mL | 0.9707 mL | |
| 30 mM | 0.0324 mL | 0.1618 mL | 0.3236 mL | 0.8090 mL | |
| 40 mM | 0.0243 mL | 0.1213 mL | 0.2427 mL | 0.6067 mL | |
| 50 mM | 0.0194 mL | 0.0971 mL | 0.1941 mL | 0.4854 mL | |
| 60 mM | 0.0162 mL | 0.0809 mL | 0.1618 mL | 0.4045 mL | |
| 80 mM | 0.0121 mL | 0.0607 mL | 0.1213 mL | 0.3034 mL |
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