Phosphorylethanolamine
Based on 4 publication(s) in Google Scholar
Phosphorylethanolamine (Monoaminoethyl phosphate) is a membrane phospholipid and an important precursor of Phosphatidylcholine (HY-B2233B). It is found in most animal tissues and various human extracranial tumors, playing a critical role in membrane integrity, cell division, mitochondrial respiratory function, and more. Studies have shown that changes in the abundance of Phosphorylethanolamine are associated with Alzheimer's disease and Parkinson's disease. Lowering the ratio of Phosphorylethanolamine to Phosphatidylcholine in the liver can improve insulin signaling. Phosphorylethanolamine holds promise for research in the fields of cancer, neurodegenerative disorders, and metabolic diseases.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.90%
- CAS 番号: 1071-23-4
- 分子式: C2H8NO4P
- 分子量:141.06
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 Phosphorylethanolamine
MoreEndogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
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Microbial Metabolite |
Human Endogenous Metabolite |
Phosphorylethanolamine (Monoaminoethyl phosphate) arrests A2058 cells at the G2/M phase of the cell cycle and inhibits their proliferation, migration, and adhesion capabilities[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A2058 cells, B16F10 cells
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Concentration:4.69-300 mM
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Incubation Time:24 h
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Result:Not only reduced viability but also blocked the capacity of A2058 cells of forming new clones.
化学情報
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CAS 番号 1071-23-4
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性状 Solid
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分子量 141.06
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分子式 C2H8NO4P
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Color White to off-white
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SMILES
NCCOP(O)(O)=O
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別名
Monoaminoethyl phosphate; NSC 254167; O-Phosphoethanolamine; ホスホリルエタノールアミン
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (4)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Cell Death Discov
SNORA14A inhibits hepatoblastoma cell proliferation by regulating SDHB-mediated succinate metabolism. [Abstract]2023 Jan 30;9(1):36. PMID: 36717552 -
Biochem Biophys Res Commun
CircRNA circBACH1 (hsa_circ_0061395) serves as a miR-656-3p sponge to facilitate hepatocellular carcinoma progression through increasing SERBP1 expression. [Abstract]2021 Jun 4:556:1-8. PMID: 33831787 -
溶剤 & 溶解度
H2O : 125 mg/mL (886.15 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (708.92 mM); Clear solution; Need ultrasonic
純度とドキュメンテーション
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データシート (272 KB)
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SDS (476 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Kinoshita Y, et al. Phosphorylethanolamine content of human brain tumors. Neurol Med Chir (Tokyo). 1994 Dec;34(12):803-6. [Content Brief]
[2]. Hui SCN, et al. In vivo spectral editing of phosphorylethanolamine. Magn Reson Med. 2022 Jan;87(1):50-56. [Content Brief]
[3]. Calzada E,et al. Phosphatidylethanolamine Metabolism in Health and Disease. Int Rev Cell Mol Biol. 2016;321:29-88. doi: 10.1016/bs.ircmb.2015.10.001. [Content Brief]
[4]. van der Veen JN, et al. A role for phosphatidylcholine and phosphatidylethanolamine in hepatic insulin signaling. FASEB J. 2019 Apr;33(4):5045-5057. [Content Brief]
[5]. Nesic I, et al. Alterations in phosphatidylethanolamine levels affect the generation of Aβ. Aging Cell. 2012 Feb;11(1):63-72. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 7.0892 mL | 35.4459 mL | 70.8918 mL | 177.2296 mL |
| 5 mM | 1.4178 mL | 7.0892 mL | 14.1784 mL | 35.4459 mL | |
| 10 mM | 0.7089 mL | 3.5446 mL | 7.0892 mL | 17.7230 mL | |
| 15 mM | 0.4726 mL | 2.3631 mL | 4.7261 mL | 11.8153 mL | |
| 20 mM | 0.3545 mL | 1.7723 mL | 3.5446 mL | 8.8615 mL | |
| 25 mM | 0.2836 mL | 1.4178 mL | 2.8357 mL | 7.0892 mL | |
| 30 mM | 0.2363 mL | 1.1815 mL | 2.3631 mL | 5.9077 mL | |
| 40 mM | 0.1772 mL | 0.8861 mL | 1.7723 mL | 4.4307 mL | |
| 50 mM | 0.1418 mL | 0.7089 mL | 1.4178 mL | 3.5446 mL | |
| 60 mM | 0.1182 mL | 0.5908 mL | 1.1815 mL | 2.9538 mL | |
| 80 mM | 0.0886 mL | 0.4431 mL | 0.8861 mL | 2.2154 mL | |
| 100 mM | 0.0709 mL | 0.3545 mL | 0.7089 mL | 1.7723 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Phosphorylethanolamine 関連分類
HY-N5034 関連分類
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