AChE-IN-119
AChE-IN-119 is a selective acetylcholinesterase (AChE) inhibitor with an IC50 of 0.0641 μM and a Ki of 0.01648 μM. AChE-IN-119 exerts antioxidant effects by scavenging DPPH free radicals. AChE-IN-119 exhibits mixed-type inhibition and interacts with both the catalytic active site and the peripheral anionic site of acetylcholinesterase. AChE-IN-119 can be used for the research of Alzheimer's disease.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C20H13ClN4O2S
- 分子量:408.86
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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AChE 0.01648 μM (Ki) |
AChE 0.0641 μM (IC50) |
AChE-IN-119 (compound 4) potently inhibits purified acetylcholinesterase (AChE) via a mixed-type inhibition mechanism, with an IC50 of 0.0641 μM. It exhibits 108-fold higher selectivity for AChE over butyrylcholinesterase (BChE), and its Ki value against AChE is 0.01648 μM[1].
AChE-IN-119 exerts antioxidant effects by scavenging DPPH free radicals, with an IC50 of 10.01 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 408.86
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分子式 C20H13ClN4O2S
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SMILES
CN(C1=CC=C(Cl)C=C1/C2=N/NC3=NC=C(C4=CC(C=CC=C5)=C5O4)S3)C2=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AChE-IN-119 関連分類
HY-184796 関連分類
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