Antitumor agent-133
Antitumor agent-133 (compound 4d) is a bis-isatin derivative, with activities against Huh1 (IC50=17.13 μM) and Huh7 (IC50=8.27 μM). Antitumor agent-133 induces cell autophagy and inhibits tumor growth through regulation of LC3BII, ATG5 and p62 proteins.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C27H24Br2N4O8
- 分子量:692.31
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| AML12 | IC50 |
>100 μM
Compound: 4d
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Antiproliferative activity against mouse AML12 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 method
Antiproliferative activity against mouse AML12 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 method
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[PMID: 38224754] |
| H22 | IC50 |
16.89 μM
Compound: 4d
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Antiproliferative activity against mouse H22 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 method
Antiproliferative activity against mouse H22 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 method
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[PMID: 38224754] |
| HepG2 | IC50 |
>100 μM
Compound: 4d
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Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 method
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 method
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[PMID: 38224754] |
| Huh-7 | IC50 |
8.27 μM
Compound: 4d
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Antiproliferative activity against human Huh-7 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 method
Antiproliferative activity against human Huh-7 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 method
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[PMID: 38224754] |
| MHCC97H | IC50 |
>100 μM
Compound: 4d
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Antiproliferative activity against human MHCC97H cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 method
Antiproliferative activity against human MHCC97H cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 method
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[PMID: 38224754] |
Antitumor agent-133 (0-100 μM, 48h) exhibits antitumor activities with IC50 values of 17.13 μM (Huh1) and 8.27μM (Huh7) and selectivity towards cancer cells [1].
Antitumor agent-133 (0-100 μM, 48h) induces cancer cell autophagy through regulating the expressions of LC3B (I and II), ATG5 and p62[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Huh1 xenograft model in NCG mice [1]
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Dosage:i.p., 15 mg/kg, once every two days for 14 days
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Administration:intraperitoneal injection
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Result:Inhibited tumor growth.
化学情報
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分子量 692.31
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分子式 C27H24Br2N4O8
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SMILES
COC([C@@H](NC(CN1C(C(C2=CC(Br)=CC=C21)=O)=O)=O)CCCCNC(CN3C(C(C4=CC(Br)=CC=C43)=O)=O)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Antitumor agent-133 関連分類
HY-157548 関連分類
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