country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-146080

Copy Link Print Information

Antitumor agent-61

Antitumor agent-61 (Compound 9b), Irinotecan (Ir) derivative, is a potential antitumor agent. Antitumor agent-61 displays potent activity with IC₅₀s of 0.92, 1.39, 1.75, 2.20, 3.05 and 3.23 μM against five human cancer cells SK-OV-3, SK-OV-3/CDDP, U2OS, MCF-7, A549 and MG-63, respectively. Antitumor agent-61 induces SK-OV-3 cells apoptosis through mitochondrion pathways.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2408917-12-2
分子式: C₅₄H₆₃FN₅O₁₀P
分子量:992.08

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

Antitumor agent-61 構造式

CAS 番号: 2408917-12-2

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Cellular Effect
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	3.05 μM Compound: 9b	Cytotoxicity against human A549 cells assessed as reduction in cell growth by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell growth by MTT assay	[PMID: 31972391]
MCF7	IC₅₀	2.2 μM Compound: 9b	Cytotoxicity against human MCF-7 cells assessed as reduction in cell growth by MTT assay Cytotoxicity against human MCF-7 cells assessed as reduction in cell growth by MTT assay	[PMID: 31972391]
MG-63	IC₅₀	3.23 μM Compound: 9b	Cytotoxicity against human MG-63 cells assessed as reduction in cell growth by MTT assay Cytotoxicity against human MG-63 cells assessed as reduction in cell growth by MTT assay	[PMID: 31972391]
SK-OV-3	IC₅₀	0.92 μM Compound: 9b	Cytotoxicity against human SK-OV-3 cells assessed as reduction in cell growth by MTT assay Cytotoxicity against human SK-OV-3 cells assessed as reduction in cell growth by MTT assay	[PMID: 31972391]
U2OS	IC₅₀	1.75 μM Compound: 9b	Cytotoxicity against human U2OS cells assessed as reduction in cell growth by MTT assay Cytotoxicity against human U2OS cells assessed as reduction in cell growth by MTT assay	[PMID: 31972391]

体外実験

Antitumor agent-61 (compound 6b) shows anti-proliferation activity with IC₅₀ values of 3.05, 2.20, 3.23, 1.75, 0.92 and 1.39 μM for A549, MCF-7, MG-63, U2OS, SK-OV-3 and SK-OV-3/CDDP cells^[1].
Antitumor agent-61 (compound 6b) (50-150 μM) shows a certain inhibitory activity against Topo I at 150 μM^[1].
Antitumor agent-61 (compound 6b) (5-10 μM; 24 hours, SK-OV-3 cells) induces apoptosis through mitochondrial pathway. Decrease the MMP level and increase ROS level in a dose-dependent manner ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

SK-OV-3 cells
Concentration:

5.0 and 10 μM
Incubation Time:

24 hours
Result:

Increased the percentage of apoptosis cells (including the early and late apoptosis) from 21.11% (5 μM) to 32.27% (10 μM), respectively and the apoptosis rate was significantly greater than that of Ir.

Cell Cycle Analysis^[1]

Cell Line:

SK-OV-3 cells
Concentration:

5.0 and 10 μM
Incubation Time:

24 hours
Result:

Increased the percentage of S stage in a dose-dependent manner.

Western Blot Analysis^[1]

Cell Line:

SK-OV-3 cells
Concentration:

5.0 and 10 μM
Incubation Time:

24 hours
Result:

Decreased the expression of antiapoptotic protein Bcl-2, while increased pro-apoptotic Bax and caspase expression.

体内実験

Antitumor agent-61 (compound 6b) (10-20 mg/kg; i.h.; Twice daily, for 28 days; BALB/c nude mice with SK-OV-3 xenograft) reduces mean NPC tumor burden in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c nude mice with SK-OV-3 xenograft^[1]
Dosage:

10 and 20 mg/kg
Administration:

Subcutaneous injection; Twice daily, for 28 days.
Result:

Suppressed tumor growth by 47.7% and 56.8% for 10 and 20 mg/kg, respectively, without affecting body weight or causing any overt adverse effects.

化学情報

CAS 番号 2408917-12-2
分子量 992.08
分子式 C₅₄H₆₃FN₅O₁₀P
SMILES

O=C(N1CCC(CC1)N2CCCCC2)OC3=CC4=C(CC)C5=C(C6=CC7=C(COC(C7(CC)OC(CCCC8=CC=C(NC(P(OCC)(OCC)=O)C9=CC=C(C=C9)F)C=C8)=O)=O)C(N6C5)=O)N=C4C=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (279 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Xiaochao Huang, et al. Synthesis, mechanisms of action, and toxicity of novel aminophosphonates derivatives conjugated irinotecan in vitro and in vivo as potent antitumor agents. Eur J Med Chem. 2020 Mar 1;189:112067. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ