Antitumor agent-62
Antitumor agent-62 (Compound 47) is a NO-releasing antitumor agent. Antitumor agent-62 shows antiproliferative activity against four cancer cell lines. Antitumor agent-62 activates mitochondrial apoptosis pathway and arrests cell cycle at G2/M phase.
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- CAS 番号: 2460735-29-7
- 分子式: C21H19N3O9S
- 分子量:489.46
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
4.18 μM
Compound: 47
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Anticancer activity against human A549 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay
Anticancer activity against human A549 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay
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[PMID: 32438251] |
| HepG2 | IC50 |
2.81 μM
Compound: 47
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Anticancer activity against human HepG2 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay
Anticancer activity against human HepG2 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay
|
[PMID: 32438251] |
| L02 | IC50 |
9.16 μM
Compound: 47
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Cytotoxicity against human L02 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human L02 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
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[PMID: 32438251] |
| MCF-10A | IC50 |
6.45 μM
Compound: 5
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Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
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[PMID: 34315044] |
| MCF7 | IC50 |
1.91 μM
Compound: 47
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Anticancer activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay
Anticancer activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay
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[PMID: 32438251] |
| MCF7 | IC50 |
2.02 μM
Compound: 5
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
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[PMID: 34315044] |
| MDA-MB-231 | IC50 |
1.39 μM
Compound: 5
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
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[PMID: 34315044] |
Antitumor agent-62 (Compound 47) shows antiproliferative activity with IC50 values of 1.23 ± 0.10, 1.91 ± 0.14, 2.81 ± 0.13, 4.18 ± 0.15 and 9.16 ± 0.38 μM against MDA-MB-231, MCF-7, HepG2, A549 and LO2 cells, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2460735-29-7
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分子量 489.46
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分子式 C21H19N3O9S
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SMILES
O=C1OC2=C(C=C1N)C=C(OC)C(OCCCOC3=NO[N+]([O-])=C3S(=O)(C4=CC=CC=C4)=O)=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Antitumor agent-62 関連分類
HY-146093 関連分類
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