country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-N12641

Copy Link Print Information

Ardisianone

Ardisianone is a component with an alkyl benzoquinone structure that can be isolated from Ardisia virens Kurz and Ardisia compressa tea extract. Ardisianone exhibits potent antileukemic activity, particularly against HL-60 cells, with IC₅₀ values of 1.87 μM (24 h) and 1.67 μM (48 h). Ardisianone induces caspase-dependent apoptosis and triggers pyroptosis. Ardisianone can be used for the study of acute myeloid leukemia (AML).

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 66398-68-3
分子式: C₂₄H₃₈O₅
分子量:406.56

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Ardisianone 構造式

CAS 番号: 66398-68-3

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Ardisianone (1-5 μM, 24-48 h) induces apoptosis and shows potent cytotoxic activity against HL-60 cells, with IC₅₀ values of 1.87 μM (24 h) and 1.67 μM (48 h)^[1].
Ardisianone (2-5 μM, 24 h) exerts pyroptosis-inducing activity in HL-60 cells^[1].
Ardisianone (0.5-2 μM, 72 h) significantly increases CD11b expression and CD68 expression, and induces differentiation into monocyte-like and macrophage-like morphologies in HL-60 cells^[1].
Ardisianone (2 μM) shows DNA damage-inducing activity in HL-60 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

HL-60 cells
Concentration:

1, 2, 3, 4, 5 μM
Incubation Time:

3, 6, 9, 12, 15, 24 h
Result:

Induced apoptosis in HL-60 cells and concentration-dependent elevation of sub-G1 apoptotic population.
Induced profound degradation of DFF45/ICAD.
Upregulated death receptors (especially TNFR2).
Downregulated IAPs (cIAP1, cIAP2, survivin).
Promoted time-dependent activation of caspase-8/-3 and degradation of Bid.

化学情報

CAS 番号 66398-68-3
分子量 406.56
分子式 C₂₄H₃₈O₅
SMILES

CCCCCCCCCCCCC[C@@H](OC(C)=O)CC(C(C(OC)=C1)=O)=CC1=O
Structure Classification
- Quinones
- Benzene Quinones
Initial Source
- Plants
- Primulaceae
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (267 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Leu WJ, et al. Antileukemic Natural Product Induced Both Apoptotic and Pyroptotic Programmed Cell Death and Differentiation Effect. Int J Mol Sci. 2021 Oct 18;22(20):11239. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ