3036136-18-9
3036136-18-9
Chemical Structure
hCAI/II-IN-8
- CAS 番号: 3036136-18-9
- Formula:C22H20N4O3
- Molecular Weight:388.42
InChIKey: HJTMMGXVJSCVTR-ZVHZXABRSA-N
SMILES: CN(C)C1=CC=C(C(OC2=CC=C(/C=N/NC(C3=CN=CC=C3)=O)C=C2)=O)C=C1
Biological Activity: hCAI/II-IN-8 (Compound 8) is a hydrazide derivative based on 4-hydroxybenzaldehyde. hCAI/II-IN-8 primarily targets human carbonic anhydrase isomerase I (hCA I) and II (hCA II) for inhibition (IC50 = 21.35 ± 0.39 nM (hCA I); 7.12 ± 0.12 nM (hCA II)). hCAI/II-IN-8 inhibits AChE and BChE as well(IC50 = 46.27 ±0.75 nM (AChE); 43.38 ± 0.83 nM (BChE)). [1].[1].
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hCAI/II-IN-8 | hCAI/II-IN-8 (Compound 8) is a hydrazide derivative based on 4-hydroxybenzaldehyde. hCAI/II-IN-8 primarily targets human carbonic anhydrase isomerase I (hCA I) and II (hCA II) for inhibition (IC50 = 21.35 ± 0.39 nM (hCA I); 7.12 ± 0.12 nM (hCA II)). hCAI/II-IN-8 inhibits AChE and BChE as well(IC50 = 46.27 ±0.75 nM (AChE); 43.38 ± 0.83 nM (BChE)). .. | |||||||||||||||||||||
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References
Keywords
