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製品番号: HY-123675

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CFI-400936

CFI-400936 is a potent TTK inhibitor with an IC₅₀ of 3.6 nM. CFI-400936 has antitumor activity.

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CAS 番号: 1338793-07-9
分子式: C₂₅H₂₇N₅O₃S
分子量:477.58

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

CFI-400936 構造式

CAS 番号: 1338793-07-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

CFI-400936 is a potent TTK inhibitor with an IC₅₀ of 3.6 nM. CFI-400936 has antitumor activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	0.16 μM Compound: 72, CFI-400936	Growth inhibition of human A549 cells after 5 days by SRB assay Growth inhibition of human A549 cells after 5 days by SRB assay	[PMID: 25043312]
HCT-116	EC₅₀	0.52 μM Compound: 72, CFI-400936	Inhibition of TTK in human HCT116 cells assessed as phosphorylation of histone H3 at Ser10 residue after 4 hrs by immunoassay Inhibition of TTK in human HCT116 cells assessed as phosphorylation of histone H3 at Ser10 residue after 4 hrs by immunoassay	[PMID: 25043312]
HCT-116	GI₅₀	0.1 μM Compound: 72, CFI-400936	Growth inhibition of human HCT116 cells after 5 days by SRB assay Growth inhibition of human HCT116 cells after 5 days by SRB assay	[PMID: 25043312]
MDA-MB-468	GI₅₀	0.66 μM Compound: 72, CFI-400936	Growth inhibition of human MDA-MB-468 cells after 5 days by SRB assay Growth inhibition of human MDA-MB-468 cells after 5 days by SRB assay	[PMID: 25043312]

化学情報

CAS 番号 1338793-07-9
分子量 477.58
分子式 C₂₅H₂₇N₅O₃S
SMILES

O=C(C(N(C)C)C1=C(CC)C=CC=C1)NC2=CC3=C(NN=C3C4=CC(S(=O)(N)=O)=CC=C4)C=C2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (268 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Laufer R, et al. Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides. Bioorg Med Chem. 2014 Sep 1;22(17):4968-97. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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