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製品番号: HY-183180

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CGRP antagonist-8

CGRP antagonist-8 is a CGRP receptor antagonist with an IC₅₀ of 2.7 nM. CGRP antagonist-8 can be used for the research of migraine.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 1610413-85-8
分子式: C₄₀H₄₇N₉O₅S
分子量:765.92

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

CGRP antagonist-8 構造式

CAS 番号: 1610413-85-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

CGRP antagonist-8 is a CGRP receptor antagonist with an IC₅₀ of 2.7 nM. CGRP antagonist-8 can be used for the research of migraine^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
SK-N-MC	EC₅₀	100 nM Compound: 8	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of alpha-CGRP-induced c-AMP formation after 15 mins by radioimmunoassay Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of alpha-CGRP-induced c-AMP formation after 15 mins by radioimmunoassay	[PMID: 24794104]

体外実験

CGRP antagonist-8 (Compound 8) potently inhibits CGRP receptor binding in SK-N-MC cell membrane tissue with an IC₅₀ of 2.7 nM^[1].
CGRP antagonist-8 acts as a CGRP receptor antagonist in SK-N-MC cells, with an EC₅₀ of 100 nM in the cAMP functional assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1610413-85-8
分子量 765.92
分子式 C₄₀H₄₇N₉O₅S
SMILES

O=C1N(C2CCN(CC2)C(N[C@@H](C(N[C@@H](CCCCN)C(N3CCN(C4=CC=NC=C4)CC3)=O)=O)CC5=CC6=CC=CC=C6S5)=O)C(NC7=CC=CC=C71)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Dasgupta B, et al. Serendipitous oxidation product of BIBN4096BS: a potent CGRP receptor antagonist. Bioorg Med Chem Lett. 2014;24(12):2744-2748. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

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