Cloxacepride
Cloxacepride is an orally active and potent antiallergic agent. Cloxacepride is a CaM (calmodulin) antagonist. Cloxacepride has anti-PCA (passive cutaneous anaphylaxis) activity.
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- CAS 番号: 65569-29-1
- 分子式: C22H27Cl2N3O4
- 分子量:468.37
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Cloxacepride (10-50 μM) shows inhibitory effect on Compound 48/80 (HY-115768)-induced histamine and serotonin release from rat mesenterial mast cells. The IC50 is determined to 21 μM (histamine) and 19 μM (serotonin)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Cloxacepride has anti-PCA activity when administered orally 15 or 60 min before antigenic challenge[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 65569-29-1
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分子量 468.37
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分子式 C22H27Cl2N3O4
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SMILES
O=C(C1=CC(Cl)=C(NC(COC2=CC=C(C=C2)Cl)=O)C=C1OC)NCCN(CC)CC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Metz G, et al. Cloxacepride and related compounds: a new series of orally active antiallergic compounds. J Med Chem. 1983 Jul;26(7):1065-70. [Content Brief]
[2]. Gigl G, et al. Calmodulin antagonism: a pharmacological approach for the inhibition of mediator release from mast cells. Cell Calcium. 1987 Oct;8(5):327-44. [Content Brief]
[3]. Friedrich G, et al. Inhibitory effect of cloxacepride on compound 48/80-induced histamine and serotonin release from rat mast cells. Arch Int Pharmacodyn Ther. 1984 Feb;267(2):264-8. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Cloxacepride 関連分類
HY-106645 関連分類
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