65569-29-1
65569-29-1
Chemical Structure
Cloxacepride
- CAS No.: 65569-29-1
- Formula:C22H27Cl2N3O4
- Molecular Weight:468.37
IUPAC Name: 5-chloro-4-(2-(4-chlorophenoxy)acetamido)-N-(2-(diethylamino)ethyl)-2-methoxybenzamide
InChIKey: VZNJZQAFQDEJOO-UHFFFAOYSA-N
SMILES: O=C(C1=CC(Cl)=C(NC(COC2=CC=C(C=C2)Cl)=O)C=C1OC)NCCN(CC)CC
Biological Activity: Cloxacepride is an orally active and potent antiallergic agent. Cloxacepride is a CaM (calmodulin) antagonist. Cloxacepride has anti-PCA (passive cutaneous anaphylaxis) activity[1][2].
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Cloxacepride | Cloxacepride is an orally active and potent antiallergic agent. Cloxacepride is a CaM (calmodulin) antagonist. Cloxacepride has anti-PCA (passive cutaneous anaphylaxis) activity. | |||||||||||||||||||||
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References
- [1]. Metz G, et al. Cloxacepride and related compounds: a new series of orally active antiallergic compounds. J Med Chem. 1983 Jul;26(7):1065-70. [Content Brief]
- [2]. Gigl G, et al. Calmodulin antagonism: a pharmacological approach for the inhibition of mediator release from mast cells. Cell Calcium. 1987 Oct;8(5):327-44. [Content Brief]
