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United States

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製品番号: HY-144793

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Deac-SS-Biotin

Deac-SS-Biotin is a potent antitumor agent with improved tumor targeting effects and reduced off-target toxicities. Deac-SS-Biotin uptakes into the cells through biotin-mediated internalization. Deac-SS-Biotin combined with DTT (Glutathione mimetic) can effectively inhibit microtubule assembly and displays greater antitumor activity.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₃₅H₄₅N₃O₁₀S₃
分子量:763.94

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Deac-SS-Biotin 構造式

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Deac-SS-Biotin (compound 9) (5 μM; 24 h) has a remarkable reduction-responsive drug release^[1].
Biotin effectively preventes Deac-SS-Biotin from binding to biotin receptor, thereby blocking the cellular uptake of Deac-SS-Biotin^[1].
Deac-SS-Biotin (5 μM, 5 μM and 10 μM DTT; 0-80 min) effectively inhibits microtubule assembly and displays greater antitumor activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

SGC-7901, A549, Hela, L929 cells
Concentration:

0-20 µM
Incubation Time:

72 h
Result:

Showed potent antiproliferative activity with IC₅₀s of 0.124, 0.085, 0.108, 4.22 µM for SGC-7901, A549, Hela, L929 cells, respectively.

Cell Viability Assay^[1]

Cell Line:

A549 cells
Concentration:

0.17 µM
Incubation Time:
Result:

Increased the cell viability from 23.6% to 68.9% with the increase of biotin concentration from 0.075 to 0.60 µM.

化学情報

分子量 763.94
分子式 C₃₅H₄₅N₃O₁₀S₃
SMILES

[H][C@]12NC(N[C@]1(CS[C@H]2CCCCC(OCCSSCCOC(N[C@H]3CCC4=C(C5=CC=C(C(C=C53)=O)OC)C=C(C(OC)=C4OC)OC)=O)=O)[H])=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Wang C,et al. Design, synthesis, and biological evaluation of biotinylated colchicine derivatives as potential antitumor agents. J Enzyme Inhib Med Chem. 2022 Dec;37(1):411-420. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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