Decarbamoylsaxitoxin
Decarbamoylsaxitoxin is a sodium channel inhibitor that blocks the influx of sodium ions through the membranes of excitable nerves and skeletal muscle cells, thereby preventing the formation of action potentials. Decarbamoylsaxitoxin is an acidic hydrolysis product of saxitoxin, and its toxic effects on mice are identical to those of saxitoxin. Decarbamoylsaxitoxin inhibits veratridine- and ouabain-induced swelling and lysis of mouse neuroblastoma cells by blocking Na+ channels. Decarbamoylsaxitoxin can be used in studies related to paralytic shellfish poisoning.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 58911-04-9
- 分子式: C9H16N6O3
- 分子量:256.26
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Endogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
Decarbamoylsaxitoxin (200-1000 pg/well, 3 nM to 300 μM; 8-24 hr) inhibits ouabain/veratridine-induced cell lysis in mouse neuroblastoma cells (ATCC no. CCL 131) with a mean relative toxicity of 42.6% compared to US FDA saxitoxin standard[2].
Decarbamoylsaxitoxin (110 μg/mL; 5 min boiled in 0.1 N or 1.0 N HCl) remains stable (toxicity unchanged) after boiling for 5 min in either 0.1 N or 1.0 N HCl, as measured in mouse neuroblastoma cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:mouse neuroblastoma cells (ATCC no. CCL 131)
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Concentration:200-1000 pg/well; 3 nM to 300 μM (tested immediately after opening sealed ampoules)
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Incubation Time:8-24 hr
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Result:Exhibited a dose-response profile in the neuroblastoma cell bioassay, with mean relative toxicity of 42.6% compared to US FDA saxitoxin standard (set at 100%).
Showed overlapping dose-response profile shape with GTX II/III-1.
Increased absorbance values of adherent stained cells with higher decarbamoylsaxitoxin concentrations.
化学情報
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CAS 番号 58911-04-9
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分子量 256.26
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分子式 C9H16N6O3
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SMILES
OC1([C@]23[C@](N=C(N3)N)([H])[C@@H](N=C(N2CC1)N)CO)O
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別名
DcSTX; DecarbamoylSTX
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Structure Classification
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Initial Source
Gonyaulax catenella
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Ghazarossian VE,et al. A biologically active acid hydrolysis product of saxitoxin. Biochem Biophys Res Commun. 1976 Feb 9;68(3):776-80. [Content Brief]
[2]. Jellett JF, et al. Toxicological evaluation of saxitoxin, neosaxitoxin, gonyautoxin II, gonyautoxin II plus III and decarbamoylsaxitoxin with the mouse neuroblastoma cell bioassay. Toxicol In Vitro. 1995;9(1):57-65. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Decarbamoylsaxitoxin 関連分類
HY-135000 関連分類
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