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製品番号: HY-P1336A

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Deltorphin I TFA

(別名: Deltorphin 1 TFA; Deltorphin C TFA; [D-Ala2] Deltorphin I TFA)

Deltorphin I TFA (Deltorphin 1 TFA; Deltorphin C TFA; [D-Ala2] Deltorphin I TFA) is a high-affinity, selective δ-opioid receptor agonist that targets the δ1 and δ2 opioid receptor subtypes. Deltorphin I TFA produces analgesic effects in the rat spinal cord. Deltorphin I TFA increases the pain threshold in rats. Deltorphin I TFA can be used in studies related to nociception (acute pain).

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CAS 番号: 2952824-50-7
分子式: C₃₉H₅₃F₃N₈O₁₂
分子量:882.88

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

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Deltorphin I TFA 構造式

CAS 番号: 2952824-50-7

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数量

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target^[1]

δ Opioid Receptor/DOR

Opioid Receptor アイソフォーム固有の製品をすべて表示 :

体内実験

Deltorphin I (0.15-15 μg; intrathecal injection; single administration) TFA exerts dose-dependent analgesic effects in acute nociception tests in rats by activating δ1 and δ2 opioid receptors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar rats (male, 260-350 g, intrathecal lumbar enlargement catheter implantation)^[1]
Dosage:

0.15 μg; 1.5 μg; 15 μg
Administration:

i.th.; single injection
Result:

Significantly increased tail-flick latency in a dose-dependent manner, with effects starting at 15 minutes post-injection and lasting for 120 minutes.
Reached maximum effect at 15 minutes for all doses, with duration of effect increasing with higher doses.
Significantly increased paw pressure threshold at 1.5 μg and 15 μg doses starting at 15 minutes post-injection; showed no effect at 0.15 μg dose.
Had its antinociceptive effect significantly antagonized by coadministration of 30 μg NTI, 3 μg NTB, or 1 μg BNTX in both tail-flick and paw pressure tests.
Had its effect completely blocked by NTI in the paw pressure test.

化学情報

CAS 番号 2952824-50-7
分子量 882.88
分子式 C₃₉H₅₃F₃N₈O₁₂
別名

Deltorphin 1 TFA; Deltorphin C TFA; [D-Ala2] Deltorphin I TFA
配列

Tyr-Ala-Phe-Asp-Val-Val-Gly
シーケンスの短縮

YAFDVVG
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Labuz D, et al. Antinociceptive effects of isoleucine derivatives of deltorphin I and deltorphin II in rat spinal cord: a search for selectivity of delta receptor subtypes. Neuropeptides. 1998;32(6):511-517. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

MOQ

Minimum order quantity

100 mg

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生物活性
- 製品説明
- IC₅₀ & Target
- 体内実験
化学情報
純度とドキュメンテーション
参考文献

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Deltorphin I TFA

Opioid Receptor アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Deltorphin I TFA 関連分類

HY-P1336A 関連分類