製品番号: HY-W013331

Deoxyartemisinin

(別名: 2-Deoxyartemisinin)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Deoxyartemisinin (2-Deoxyartemisinin) is an orally active anti-inflammatory and analgesic agent. Deoxyartemisinin selectively reduces the level of the pro-inflammatory cytokine TNF-α. Deoxyartemisinin alleviates neuropathic pain, inflammatory pain, and croton oil-induced ear edema.\nDeoxyartemisinin exerts an analgesic effect against thermal stimulation. Deoxyartemisinin has anti-ulcer activity. Deoxyartemisinin can be used in research related to inflammatory diseases, pain, and gastric ulcers.

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純度: 98.76%
CAS 番号: 72826-63-2
分子式: C₁₅H₂₂O₄
分子量:266.33

保管条件:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Deoxyartemisinin 構造式

CAS 番号: 72826-63-2

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生物活性
- 製品説明
- Cellular Effect
- Parmacokinetics
- 体内実験
化学情報
Publications (1)
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
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生物活性

製品説明

TNF Receptor アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	>50 μM Compound: DART	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by Cell-titer Glo luminescent assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by Cell-titer Glo luminescent assay	[PMID: 38287228]
HUVEC	IC₅₀	>50 μM Compound: 12	Inhibitory activity against human umbilical vein endothelial cells (HUVEC) was assayed using MTT colorimetric proliferation assay Inhibitory activity against human umbilical vein endothelial cells (HUVEC) was assayed using MTT colorimetric proliferation assay	[PMID: 14552753]

Parmacokinetics

Species	Dose	Route	T_1/2	T_max	C_max	AUC_last	AUC_inf	MRT_last	C₀	V_z	CL
Rat^[2]	5 mg/kg	i.v.	1.45 h	/	/	219 ng·h/mL	222 ng·h/mL	0.671 h	1069 ng/mL	48.3 L/kg	385 mL/min/kg
Rat^[2]	100 mg/kg	p.o.	1.12 h	0.389 h	62.4 ng/mL	67.3 ng·h/mL	71.0 ng·h/mL	1.21 h	/	/	/

体内実験

Deoxyartemisinin (10-300 mg/kg; i.p.; single administration) reduces formaldehyde-induced neuropathic pain by 56.55% and inflammatory pain by 45.43% in male Swiss mice, exerts dose-dependent analgesic effects in the tail-flick test, and impairs spontaneous activity and motor coordination in male Swiss mice at the dose of 300 mg/kg^[1].
Deoxyartemisinin (100 mg/kg; i.p.; single administration) reduces croton oil-induced ear swelling by 33.64% and selectively decreases TNF-α levels by 37.37% in male Swiss mice^[1].
Deoxyartemisinin (50-200 mg/kg; p.o.; single administration) dose-dependently reduces the gastric ulcer injury index in ethanol-induced male Wistar rats, with an ED₅₀ of 87.5 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Swiss mice (male, 25-35 g)^[1]
Dosage:

10 mg/kg; 30 mg/kg; 100 mg/kg
Administration:

i.p.; single dose
Result:

Reduced neurogenic pain by 0% and inflammatory pain by 1.69% (10 mg/kg).
Reduced neurogenic pain by 9.26% and inflammatory pain by 0% (30 mg/kg).
Reduced neurogenic pain by 56.55% and inflammatory pain by 45.43% (100 mg/kg).
Exerted a dose-dependent antinociceptive effect in the tail flick test

Animal Model:

Swiss mice (male, 25-35 g)^[1]
Dosage:

100 mg/kg
Administration:

i.p.; single dose
Result:

Reduced croton oil-induced ear edema by 33.64% compared to vehicle group.
Selectively reduced tumor necrosis factor alpha (TNF-α) levels by 37.37%, with no significant reduction in interleukin-1beta (IL-1β) or interleukin-6 (IL-6) levels.

Animal Model:

Wistar rats (male, 200-300 g)^[1]
Dosage:

50 mg/kg; 100 mg/kg; 200 mg/kg
Administration:

p.o.; single dose
Result:

Reduced ulcerative lesion index by 49.7% (50 mg/kg).
Reduced ulcerative lesion index by 74% (100 mg/kg).
Reduced ulcerative lesion index by 76.5% (200 mg/kg).
Had an effective dose 50 (ED50) of 87.5 mg/kg.

化学情報

CAS 番号 72826-63-2
性状 Solid
分子量 266.33
分子式 C₁₅H₂₂O₄
Color White to off-white
SMILES

C[C@@H]1[C@@](CC[C@H]2C)([H])[C@@]([C@@]2([H])CC3)(O4)[C@@](OC1=O)([H])O[C@@]34C
別名

2-Deoxyartemisinin
Initial Source

Nocardia cwallina
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Structure

Antimalarial drug artemisinin stabilizes PfRACK1 binding to the ribosome. [Abstract]

2025 May 27:S0969-2126(25)00186-8. PMID: 40480224

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (280 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Favero FF, et al. Artemisinin and deoxyartemisinin isolated from Artemisia annua L. promote distinct antinociceptive and anti-inflammatory effects in an animal model. Biomed Pharmacother. 2024;178:117299. [Content Brief]

[2]. Fu C, et al. Oral Bioavailability Comparison of Artemisinin, Deoxyartemisinin, and 10-Deoxoartemisinin Based on Computer Simulations and Pharmacokinetics in Rats. ACS Omega. 2020;6(1):889-899. Published 2020 Dec 28. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Deoxyartemisinin

1 Cited Publications

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Deoxyartemisinin

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MedChemExpress（MCE）の使用を引用している文献 Deoxyartemisinin

TNF Receptor アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (1)

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Deoxyartemisinin 関連分類

製品番号: HY-W013331