country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-181662

Copy Link Print Information

DLK-IN-2

DLK-IN-2 is a selective inhibitor of DLK and neuroprotective agent. DLK-IN-2 shows no significant inhibition against CYPs 3A4, 2D6 and 2C9. DLK-IN-2 inhibits acute axonal palmitoylation of DLK, blocks DLK-dependent pro-degenerative axon-to-soma retrograde signaling and suppresses c-Jun phosphorylation. DLK-IN-2 can be used for the mechanistic study of neurodegenerative diseases.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 883012-32-6
分子式: C₂₃H₂₅ClN₂O₃S
分子量:444.97

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

DLK-IN-2 構造式

CAS 番号: 883012-32-6

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target^[1]

MAP3K12/DLK

MAP3K アイソフォーム固有の製品をすべて表示 :

体外実験

DLK-IN-2 (compound 13) (10 μM; 1 h pre-incubation, 2.5 h post-deprivation) significantly inhibits trophic factor deprivation-induced c-Jun phosphorylation in primary embryonic day 16 rat DRG neurons^[1].
DLK-IN-2 (10 μM; 1 h pre-incubation, 45 h post-deprivation) significantly protects primary embryonic day 16 rat DRG neurons from trophic factor deprivation-induced neurodegeneration^[1].
DLK-IN-2 (10 μM; 4 h post-injury) transiently reduces acute axotomy-induced Wallerian degeneration in primary embryonic day 16 rat DRG neuron spot cultures, but does not protect axons at 6 h post-injury^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Embryonic rat DRG neurons
Concentration:

10 μM
Incubation Time:

2.5 h (p-c-Jun); 4 h (NMNAT2, STMN2)
Result:

Significantly reduced TD-induced c-Jun phosphorylation; did not stabilize NMNAT2 or STMN2.

化学情報

CAS 番号 883012-32-6
分子量 444.97
分子式 C₂₃H₂₅ClN₂O₃S
SMILES

O=S(C1=CC=C(NC(C2=CC=C(Cl)C=C2)=O)C=C1)(NC34CC5CC(C4)CC(C5)C3)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (272 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Zhang X, et al. Combinatorial chemistry identifies additional compounds that selectively inhibit DLK-dependent retrograde signaling while minimally affecting other axonal roles of DLK. Sci Rep. 2026;16(1):3892. Published 2026 Jan 27. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ

Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

製品名:
製品番号:
数量:
日本の代理先をお選びください:

製品名:
CAS 番号:
生物種:
純度:
数量:

DLK-IN-2

MAP3K アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

DLK-IN-2 関連分類

HY-181662 関連分類