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製品番号: HY-P990995A

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Etalanetug (Mouse IgG2a)

(別名: 7G6 Antibody; 7G6-IgG2a)

Etalanetug (Mouse IgG2a) (7G6 Antibody) is a mouse monoclonal antibody targeting the HVPGG motif in the microtubule-binding domain of tau protein. Etalanetug (Mouse IgG2a) reduces the levels of insoluble tau protein in multiple brain regions and inhibits the seeding and spread of pathological tau protein. Etalanetug (Mouse IgG2a) is applicable to research related to Alzheimer's disease.

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CAS 番号: 2690265-18-8

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Etalanetug (Mouse IgG2a) 構造式

CAS 番号: 2690265-18-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Etalanetug (Mouse IgG2a) binds to recombinant wild-type human 2N4R tau protein with high affinity, with a K_d value of 64 pM^[1].
Etalanetug (Mouse IgG2a) binds to recombinant human P301S mutant 2N4R tau protein with high affinity, with a K_d value of 448 pM, which is lower than its affinity for recombinant wild-type human 2N4R tau protein^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Etalanetug (Mouse IgG2a) (3-40 mg/kg; peripheral administration) significantly reduces insoluble tau levels in multiple brain regions in the hTau transgenic mouse model of Alzheimer's disease^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

hTau mice (6 months old) with AD brain‑derived seed‑injection into the left hippocampus^[2]
Dosage:

3, 10, 40 mg/kg
Administration:

Peripheral administration
Result:

Rduced insoluble tau in the hippocampus and cortex of seeded hTau mice, and antibody target engagement in CSF increased in a dose‑dependent manner.
Reduced pathological tau seeding and spreading in this model.

Format

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化学情報

CAS 番号 2690265-18-8
別名

7G6 Antibody; 7G6-IgG2a
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

Inhibitory Antibodies User Guide (603 KB)

参考文献

[1]. Roberts M, et al. Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer's disease. Acta Neuropathol Commun. 2020;8(1):13. Published 2020 Feb 4. [Content Brief]

[2]. Talma S, et al. Efficacy of the murine version of E2814 in a validated AD brain seed‐injection model in hTau mice. Alzheimer's & Dementia. 2023 Dec;19:e076853.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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