LILRB1 - leukocyte immunoglobulin like receptor B1 Gene

Also Known as ILT2; LIR1; MIR7; PIRB; CD85J; ILT-2; LIR-1; MIR-7; PIR-B

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 10859

About LILRB1

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,616,322-54,638,022 (from NCBI)

This gene has 13 transcripts (splice variants), 1 gene allele, 304 orthologues and 25 paralogues. Biased expression in appendix (RPKM 25.9), spleen (RPKM 20.5) and 10 other tissues.

Summary

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

LILRB1 Products (10)

mRNA Protein Name
NM_001081637.3 NP_001075106.2 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 2 precursor
NM_001081638.4 NP_001075107.2 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 3 precursor
NM_001081639.4 NP_001075108.2 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 4 precursor
NM_001278398.2 NP_001265327.2 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 5 precursor
NM_001278399.2 NP_001265328.2 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 6 precursor
NM_001388355.1 NP_001375284.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 3 precursor
NM_001388356.1 NP_001375285.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 4 precursor
NM_001388357.1 NP_001375286.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 3 precursor
NM_001388358.1 NP_001375287.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 2 precursor
NM_006669.7 NP_006660.4 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables HLA-A specific inhibitory MHC class I receptor activity IDA
IDA: Inferred from direct assay
18684926 GOA
enables HLA-B specific inhibitory MHC class I receptor activity IDA
IDA: Inferred from direct assay
11907092 GOA
enables MHC class I protein binding IDA
IDA: Inferred from direct assay
9842885 GOA
enables MHC class I protein binding IMP
IMP: Inferred from mutant phenotype
18398485 GOA
enables MHC class I protein binding IPI
IPI: Inferred from physical interaction
9285411 GOA
enables MHC class I receptor activity IDA
IDA: Inferred from direct assay
9285411 GOA
enables MHC class Ib protein binding IDA
IDA: Inferred from direct assay
11169396 GOA
enables MHC class Ib protein complex binding IDA
IDA: Inferred from direct assay
17056715 GOA
enables MHC class Ib receptor activity IDA
IDA: Inferred from direct assay
24453251 GOA
enables SH2 domain binding IDA
IDA: Inferred from direct assay
11907092 GOA
NOT enables amyloid-beta binding IDA
IDA: Inferred from direct assay
24052308 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11169396 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
21213105 GOA
enables protein phosphatase 1 binding IPI
IPI: Inferred from physical interaction
9285411 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in Fc receptor mediated inhibitory signaling pathway IDA
IDA: Inferred from direct assay
9842885 GOA
involved in T cell proliferation involved in immune response IDA
IDA: Inferred from direct assay
18094328 GOA
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
18094328 GOA
involved in defense response to virus IDA
IDA: Inferred from direct assay
15585844 GOA
involved in dendritic cell differentiation IEP
IEP: Inferred from expression pattern
18094328 GOA
involved in negative regulation of CD8-positive, alpha-beta T cell activation IDA
IDA: Inferred from direct assay
21213105 GOA
involved in negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IDA
IDA: Inferred from direct assay
18094328 GOA
involved in negative regulation of T cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
21213105 GOA
involved in negative regulation of T cell proliferation IDA
IDA: Inferred from direct assay
15585844 GOA
involved in negative regulation of alpha-beta T cell activation IDA
IDA: Inferred from direct assay
21213105 GOA
involved in negative regulation of calcium ion transport IDA
IDA: Inferred from direct assay
9842885 GOA
involved in negative regulation of cell cycle IDA
IDA: Inferred from direct assay
21551166 GOA
involved in negative regulation of cytokine production involved in immune response IDA
IDA: Inferred from direct assay
18094328 GOA
involved in negative regulation of dendritic cell apoptotic process IDA
IDA: Inferred from direct assay
18094328 GOA
involved in negative regulation of dendritic cell differentiation IMP
IMP: Inferred from mutant phenotype
18684926 GOA
involved in negative regulation of endocytosis IDA
IDA: Inferred from direct assay
18094328 GOA
involved in negative regulation of interferon-beta production IDA
IDA: Inferred from direct assay
21213105 GOA
involved in negative regulation of interleukin-10 production IDA
IDA: Inferred from direct assay
18094328 GOA
involved in negative regulation of interleukin-12 production IDA
IDA: Inferred from direct assay
18094328 GOA
involved in negative regulation of mononuclear cell proliferation IDA
IDA: Inferred from direct assay
21551166 GOA
involved in negative regulation of natural killer cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
12874224 GOA
involved in negative regulation of osteoclast development IDA
IDA: Inferred from direct assay
18802077 GOA
involved in negative regulation of serotonin secretion IDA
IDA: Inferred from direct assay
11907092 GOA
involved in negative regulation of transforming growth factor beta production IDA
IDA: Inferred from direct assay
18094328 GOA
involved in negative regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
18684926 GOA
involved in negative regulation of type II interferon production IDA
IDA: Inferred from direct assay
17869268 GOA
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
21551166 GOA
involved in positive regulation of defense response to virus by host IDA
IDA: Inferred from direct assay
18398485 GOA
involved in positive regulation of gamma-delta T cell activation involved in immune response IDA
IDA: Inferred from direct assay
21233315 GOA
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
18094328 GOA
involved in positive regulation of macrophage cytokine production IDA
IDA: Inferred from direct assay
19304799 GOA
involved in positive regulation of type II interferon production IDA
IDA: Inferred from direct assay
11907092 GOA
involved in response to virus IDA
IDA: Inferred from direct assay
9285411 GOA
involved in signal transduction IDA
IDA: Inferred from direct assay
18802077 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in cytoplasm IDA
IDA: Inferred from direct assay
15585844 GOA
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
9285411 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LILRB1 Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (64 - 154)

Ig_3

Ig_3: Immunoglobulin domain (160 - 235)

Ig_2

Ig_2: Immunoglobulin domain (261 - 353)

Ig_3

Ig_3: Immunoglobulin domain (363 - 436)

  • 0
  • 200
  • 400
  • 600
  • 701 a.a.
Protein Preferred Names Protein Names

leukocyte immunoglobulin-like receptor subfamily B member 1

  • CD85 antigen-like family member J

LILRB1 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
LILRB1 Q8NHL6 HLA-G Homo sapiens P17693
SPR
16455647
Intra
LILRB1 Q8NHL6 PTPN6 Homo sapiens P29350
Anti Bait CoIP
18802077
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LILRB1 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P70179 LILRB1/CD85j/ILT2 Protein, Human (HEK293, His) ADJ55949.1 (G24-H458) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77980 LILRB1/CD85j/ILT2 Domain1&2 Protein, Human (HEK293, His) Q8NHL6-1 (G24-G221) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P77981 LILRB1/CD85j/ILT2 Protein, Human (346a.a, HEK293, His) Q8NHL6-1 (L116-V461) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P77982 LILRB1/CD85j/ILT2 Protein, Human (HEK293, mFc) Q8NHL6-1 (G24-H458) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P77985 LILRB1/CD85j/ILT2 Protein, Human (HEK293, His-Avi) Q8NHL6-1 (G24-H458) ≥ 95%, as determined by Bis-Tris PAGE.

LILRB1 抗体

製品番号 製品名 アプリケーション 反応性
HY-P81516 LILRB1 Antibody (YA1261) IHC-P Human
HY-P81516A LILRB1 Antibody (YA1261)(PBS only) IHC-P Human
HY-P84680 LILRB1 Antibody (YA4377) WB, ELISA Human
HY-P84680A LILRB1 Antibody (YA4377)(PBS only) WB, ELISA Human

関連疾患

Diseases Alias
Human Cytomegalovirus Infection

  • Cytomegalovirus Infection

  • Cytomegalovirus Infections
Malaria

  • Malaria, Susceptibility To

  • Malaria, Resistance To

  • Malaria, Cerebral

  • Cerebral Malaria

  • Malaria, Severe, Susceptibility To

  • Malaria, Severe, Resistance To

  • Malaria, Cerebral, Susceptibility To

  • Induced Malaria

  • Malaria, Vivax, Protection Against

  • Malaria, Severe

  • Malaria, Cerebral, Reduced Risk Of

  • Malaria, Protection Against

  • Resistance To Malaria Due To G6pd Deficiency

  • Malaria Due To G6pd Deficiency

  • Malarial Encephalitis

  • CM

  • Malaria Cerebral

  • Susceptibility To Malaria

  • Acute Pernicious Fever

  • Aestivo-Autumnal Fever

  • Aestivo Autumnal Malaria

  • Chagres Fever

  • Continued Malaria Fever

  • Estivo-Autumnal Fever

  • Estivo-Autumnal Malaria

  • Estivo-Autumnal Malarial Fever

  • Falciparum Fever

  • Malignant Tertian Fever

  • Malignant Tertian Malaria

  • Pernicious Intermittent Fever

  • Pernicious Malaria

  • Quotidian Malaria

  • Subtertian Fever

  • Subtertian Malaria Fever

  • Subtertian Malignant Tertian Malaria

  • Tropical Malaria

  • Algid Malaria

  • Bilious Haemoglobinuric Fever

  • Black Water Fever

  • Blackwater Fever

  • Malarial Blackwater Fever

  • Severe Malarial Falciparum

  • West African Fever

  • Malarial Haematinuria

  • Haemoglobinuric Fever

  • Haemoglobinuric Malaria

  • Severe Plasmodium Falciparum Malaria

  • Malarial Haemoglobinuria

  • Malarial Haematuria

  • Falciparum Malaria [Malignant Tertian]

  • Malaria Tropica

  • Malarial Shock

  • Chagres Virus Disease

  • Malignant Malaria

  • Mtm - [Malignant Tertian Malaria]

  • Tm -[Malignant Tertian Malaria]

  • Panama Fever

  • St - [Subtertian Malaria]

  • Malarial Quotidian

  • Benign Tertian Malaria

  • Tertian Ague

  • Vivax Fever

  • Plasmodium Vivax Malaria Nos

  • Btm - [Benign Tertian Malaria]

  • Bt - [Benign Tertian Malaria]

  • Vivax Malaria

  • Benign Tertian Vivax Malaria

  • Tertian Malaria

  • Quartan Malaria

  • Quartan Ague

  • Quartan Fever

  • Plasmodium Malariae Malaria Nos

  • Quartan Malarial

  • Malaria By Plasmodium Malariae

  • Malariae Malaria

  • Ovale Tertian Malaria

  • Plasmodium Ovale Fever

  • Malaria Fever By Plasmodium Ovale

  • Ovale Malaria

  • Malaria By Plasmodium Ovale

  • Malarial Ovale

  • Marsh Fever

  • Remittent Congestive Fever

  • Coastal Fever

  • Remittent Gastric Fever

  • Miasmatic Fever

  • Congestive Remittent Fever

  • Intermittent Fever

  • Jungle Fever

  • Paludism

  • Cameroon Fever

  • Ague

  • Corsican Fever

  • Intermittent Bilious Fever

  • Disease Due To Plasmodiidae

  • Malarial Fever

  • Plasmodiosis

  • Remittent Fever

  • Roman Fever

  • Malaria Fever Nos

  • Malaria Nos

  • Paludal Fever

  • Clinically Diagnosed Malaria

  • Clinically Diagnosed Malaria Without Parasitological Confirmation

  • Congestive Fever

  • Malarial Cachexia

  • Marsh Cachexia

  • Paludal Cachexia

  • Recurrent Malaria

  • Remittent Malaria
Bare Lymphocyte Syndrome, Type I

  • Hla Class I Deficiency

  • Mhc Class I Deficiency

  • Bls, Type I

  • Bare Lymphocyte Syndrome Type I

  • Bare Lymphocyte Syndrome, Type I, Due To Tap2 Deficiency

  • Blsi

  • Mhc Class 1 Deficiency

  • Major Histocompatibility Complex Class 1 Deficiency

  • Bare Lymphocyte Syndrome 1

  • BLS1

  • Bls I

  • Bls Type I

  • Bl-1

  • Bare Lymphocyte Syndrome Type 1

  • Immunodeficiency By Defective Expression Of Hla - [Human Leukocyte Antigen] Class 1

  • Scid - [Severe Combined Immunodeficiency] Due To Absent Class 2 Hla Antigens

  • Bls - [Bare Lymphocyte Syndrome] Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase

Clinical Phase

阻害性抗体 (1)
製品番号 製品名 製品効果
純度 Phase
HY-P991727 Zamristobart Inhibitor 96.62% Phase 2

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus LILRB1 MGD MGI:894311