LILRB1 Antibody (YA1261)(PBS only)

Cat. No.: HY-P81516A: Ficha de datos User Guide for Antibodies
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LILRB1 Antibody (YA1261) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LILRB1.

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Tamaño		Stock
50 μL		Obtener un presupuesto
100 μL		Obtener un presupuesto

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Descripciòn

Descripciòn

LILRB1 Antibody (YA1261) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LILRB1.

Host

Rabbit

Peso molecular

Predicted band size: 71 kDa;

Observed band size: 110 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q8NHL6

Gene ID

10859 [NCBI]

Immunogen

A synthesized peptide derived from human LILRB1

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:100-1:200

Pureza	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Envío

Shipping with blue ice.

Background

Function：Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:16455647, PubMed:28636952). Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11907092, PubMed:9285411, PubMed:9842885). Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (PubMed:16455647). Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells (PubMed:19304799, PubMed:29262349). Reprograms B cells toward an immune suppressive phenotype (PubMed:24453251)

Subcellular Localization：Cell membrane; Single-pass type I membrane protein; Secreted

Expression：
Tissue_specificity:Expression (protein level) in B cells, monocytes, and various dendritic cell (DC) subsets (including myeloid, plasmacytoid, and tolerant DCs) (PubMed:20448110, PubMed:24453251, PubMed:9285411, PubMed:9842885) . Expression (protein level) in decidual macrophages (PubMed:19304799) . Expression (protein level) in decidual NK cells (PubMed:29262349) .

Isoforms & Post-Translational Modification：Q8NHL6 has 5 isomers: Q8NHL6-1: 70819 Da (predicted); Q8NHL6-2: 70890 Da (predicted); Q8NHL6-3: 71019 Da (predicted); Q8NHL6-4: 70948 Da (predicted); Q8NHL6-5: 49356 Da (predicted).
Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6

Subunit：Binds PTPN6 when phosphorylated (PubMed:9285411). Binds FCER1A and FCGR1A (PubMed:11907092, PubMed:9842885). Interacts with human cytomegalovirus/HHV-5 protein UL18 (PubMed:10591185). Interacts with peptide-bound HLA-G-B2M complex (PubMed:16455647). Interacts with peptide-bound HLA-F-B2M complex but not with peptide-free HLA-F open conformer. It does not probe the peptide sequence directly (PubMed:28636952)

Research Field

Immunology

Synonyms

LILRB1; ILT2; LIR1 ; MIR7; Leukocyte immunoglobulin-like receptor subfamily B member 1; LIR-1 ; Leukocyte immunoglobulin-like receptor 1; CD85j ; CD85 antigen-like family member J

Documentación

User Guide for Antibodies (1077 KB)