LILRB1 - leukocyte immunoglobulin like receptor B1 Gene

Also Known as ILT2; LIR1; MIR7; PIRB; CD85J; ILT-2; LIR-1; MIR-7; PIR-B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10859

About LILRB1

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,616,322-54,638,022 (from NCBI)

This gene has 13 transcripts (splice variants), 1 gene allele, 304 orthologues and 25 paralogues. Biased expression in appendix (RPKM 25.9), spleen (RPKM 20.5) and 10 other tissues.

Summary

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

LILRB1 Products (10)

mRNA	Protein	Name
NM_001081637.3	NP_001075106.2	leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 2 precursor
NM_001081638.4	NP_001075107.2	leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 3 precursor
NM_001081639.4	NP_001075108.2	leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 4 precursor
NM_001278398.2	NP_001265327.2	leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 5 precursor
NM_001278399.2	NP_001265328.2	leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 6 precursor
NM_001388355.1	NP_001375284.1	leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 3 precursor
NM_001388356.1	NP_001375285.1	leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 4 precursor
NM_001388357.1	NP_001375286.1	leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 3 precursor
NM_001388358.1	NP_001375287.1	leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 2 precursor
NM_006669.7	NP_006660.4	leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables HLA-A specific inhibitory MHC class I receptor activity	IDA IDA: Inferred from direct assay	18684926	GOA
enables HLA-B specific inhibitory MHC class I receptor activity	IDA IDA: Inferred from direct assay	11907092	GOA
enables MHC class I protein binding	IDA IDA: Inferred from direct assay	9842885	GOA
enables MHC class I protein binding	IMP IMP: Inferred from mutant phenotype	18398485	GOA
enables MHC class I protein binding	IPI IPI: Inferred from physical interaction	9285411	GOA
enables MHC class I receptor activity	IDA IDA: Inferred from direct assay	9285411	GOA
enables MHC class Ib protein binding	IDA IDA: Inferred from direct assay	11169396	GOA
enables MHC class Ib protein complex binding	IDA IDA: Inferred from direct assay	17056715	GOA
enables MHC class Ib receptor activity	IDA IDA: Inferred from direct assay	24453251	GOA
enables SH2 domain binding	IDA IDA: Inferred from direct assay	11907092	GOA
NOT enables amyloid-beta binding	IDA IDA: Inferred from direct assay	24052308	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11169396	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	21213105	GOA
enables protein phosphatase 1 binding	IPI IPI: Inferred from physical interaction	9285411	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Fc receptor mediated inhibitory signaling pathway	IDA IDA: Inferred from direct assay	9842885	GOA
involved in T cell proliferation involved in immune response	IDA IDA: Inferred from direct assay	18094328	GOA
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	18094328	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	15585844	GOA
involved in dendritic cell differentiation	IEP IEP: Inferred from expression pattern	18094328	GOA
involved in negative regulation of CD8-positive, alpha-beta T cell activation	IDA IDA: Inferred from direct assay	21213105	GOA
involved in negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	IDA IDA: Inferred from direct assay	18094328	GOA
involved in negative regulation of T cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	21213105	GOA
involved in negative regulation of T cell proliferation	IDA IDA: Inferred from direct assay	15585844	GOA
involved in negative regulation of alpha-beta T cell activation	IDA IDA: Inferred from direct assay	21213105	GOA
involved in negative regulation of calcium ion transport	IDA IDA: Inferred from direct assay	9842885	GOA
involved in negative regulation of cell cycle	IDA IDA: Inferred from direct assay	21551166	GOA
involved in negative regulation of cytokine production involved in immune response	IDA IDA: Inferred from direct assay	18094328	GOA
involved in negative regulation of dendritic cell apoptotic process	IDA IDA: Inferred from direct assay	18094328	GOA
involved in negative regulation of dendritic cell differentiation	IMP IMP: Inferred from mutant phenotype	18684926	GOA
involved in negative regulation of endocytosis	IDA IDA: Inferred from direct assay	18094328	GOA
involved in negative regulation of interferon-beta production	IDA IDA: Inferred from direct assay	21213105	GOA
involved in negative regulation of interleukin-10 production	IDA IDA: Inferred from direct assay	18094328	GOA
involved in negative regulation of interleukin-12 production	IDA IDA: Inferred from direct assay	18094328	GOA
involved in negative regulation of mononuclear cell proliferation	IDA IDA: Inferred from direct assay	21551166	GOA
involved in negative regulation of natural killer cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	12874224	GOA
involved in negative regulation of osteoclast development	IDA IDA: Inferred from direct assay	18802077	GOA
involved in negative regulation of serotonin secretion	IDA IDA: Inferred from direct assay	11907092	GOA
involved in negative regulation of transforming growth factor beta production	IDA IDA: Inferred from direct assay	18094328	GOA
involved in negative regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	18684926	GOA
involved in negative regulation of type II interferon production	IDA IDA: Inferred from direct assay	17869268	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	21551166	GOA
involved in positive regulation of defense response to virus by host	IDA IDA: Inferred from direct assay	18398485	GOA
involved in positive regulation of gamma-delta T cell activation involved in immune response	IDA IDA: Inferred from direct assay	21233315	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	18094328	GOA
involved in positive regulation of macrophage cytokine production	IDA IDA: Inferred from direct assay	19304799	GOA
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	11907092	GOA
involved in response to virus	IDA IDA: Inferred from direct assay	9285411	GOA
involved in signal transduction	IDA IDA: Inferred from direct assay	18802077	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15585844	GOA
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	9285411	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LILRB1 Protein Structure

Ig_2

Ig_3

Ig_2

Ig_3

0
200
400
600
701 a.a.

Protein Preferred Names	Protein Names
leukocyte immunoglobulin-like receptor subfamily B member 1	CD85 antigen-like family member J

LILRB1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LILRB1	Q8NHL6	HLA-G	Homo sapiens	P17693	SPR	16455647
Intra	LILRB1	Q8NHL6	PTPN6	Homo sapiens	P29350	Anti Bait CoIP	18802077

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LILRB1 Proteins

Cat. No.	상품명	Accession	Purity
HY-P70179	LILRB1/CD85j/ILT2 Protein, Human (HEK293, His)	ADJ55949.1 (G24-H458)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77980	LILRB1/CD85j/ILT2 Domain1&2 Protein, Human (HEK293, His)	Q8NHL6-1 (G24-G221)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77981	LILRB1/CD85j/ILT2 Protein, Human (346a.a, HEK293, His)	Q8NHL6-1 (L116-V461)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77982	LILRB1/CD85j/ILT2 Protein, Human (HEK293, mFc)	Q8NHL6-1 (G24-H458)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77985	LILRB1/CD85j/ILT2 Protein, Human (HEK293, His-Avi)	Q8NHL6-1 (G24-H458)	≥ 95%, as determined by Bis-Tris PAGE.

LILRB1 Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P81516	LILRB1 Antibody (YA1261)	IHC-P	Human
HY-P81516A	LILRB1 Antibody (YA1261)(PBS only)	IHC-P	Human
HY-P84680	LILRB1 Antibody (YA4377)	WB, ELISA	Human
HY-P84680A	LILRB1 Antibody (YA4377)(PBS only)	WB, ELISA	Human

Related Diseases

Diseases	Alias
Human Cytomegalovirus Infection	Cytomegalovirus Infection Cytomegalovirus Infections
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Bare Lymphocyte Syndrome, Type I	Hla Class I Deficiency Mhc Class I Deficiency Bls, Type I Bare Lymphocyte Syndrome Type I Bare Lymphocyte Syndrome, Type I, Due To Tap2 Deficiency Blsi Mhc Class 1 Deficiency Major Histocompatibility Complex Class 1 Deficiency Bare Lymphocyte Syndrome 1 BLS1 Bls I Bls Type I Bl-1 Bare Lymphocyte Syndrome Type 1 Immunodeficiency By Defective Expression Of Hla - [Human Leukocyte Antigen] Class 1 Scid - [Severe Combined Immunodeficiency] Due To Absent Class 2 Hla Antigens Bls - [Bare Lymphocyte Syndrome] Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	상품명	효과	Purity	Phase
HY-P991727	Zamristobart	Inhibitor	96.62%	Phase 2

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LILRB1	MGD	MGI:894311