2. Gene
  3. LILRB1 - leukocyte immunoglobulin like receptor B1 Gene

LILRB1 - leukocyte immunoglobulin like receptor B1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ILT2; LIR1; MIR7; PIRB; CD85J; ILT-2; LIR-1; MIR-7; PIR-B

Gene ID: 10859 | Gene type: protein coding

About LILRB1

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,616,322-54,638,022 (from NCBI)

This gene has 13 transcripts (splice variants), 1 gene allele, 304 orthologues and 25 paralogues. Biased expression in appendix (RPKM 25.9), spleen (RPKM 20.5) and 10 other tissues.

Summary

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

LILRB1 Products(10)

mRNA Protein Name
NM_001081637.3 NP_001075106.2 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 2 precursor
NM_001081638.4 NP_001075107.2 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 3 precursor
NM_001081639.4 NP_001075108.2 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 4 precursor
NM_001278398.2 NP_001265327.2 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 5 precursor
NM_001278399.2 NP_001265328.2 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 6 precursor
NM_001388355.1 NP_001375284.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 3 precursor
NM_001388356.1 NP_001375285.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 4 precursor
NM_001388357.1 NP_001375286.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 3 precursor
NM_001388358.1 NP_001375287.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 2 precursor
NM_006669.7 NP_006660.4 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 1 precursor

LILRB1 Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (64 - 154)

Ig_3

Ig_3: Immunoglobulin domain (160 - 235)

Ig_2

Ig_2: Immunoglobulin domain (261 - 353)

Ig_3

Ig_3: Immunoglobulin domain (363 - 436)

  • 0
  • 200
  • 400
  • 600
  • 701 a.a.
Protein Preferred Names Protein Names

leukocyte immunoglobulin-like receptor subfamily B member 1

CD85 antigen-like family member J

Recombinant LILRB1 Proteins

Cat. No. Product Name Accession Purity
HY-P70179 LILRB1/CD85j/ILT2 Protein, Human (435a.a, HEK293, His) ADJ55949.1 (G24-H458) ≥95%
HY-P77980 LILRB1/CD85j/ILT2 Protein (Domain1&2), Human (HEK293, His) Q8NHL6 (G24-G221) ≥95%
HY-P77981 LILRB1/CD85j/ILT2 Protein, Human (346a.a, HEK293, His) Q8NHL6 (L116-V461) ≥95%
HY-P77982 LILRB1/CD85j/ILT2 Protein, Human (HEK293, mFc) Q8NHL6 (G24-H458) ≥95%
HY-P77985 LILRB1/CD85j/ILT2 Protein, Human (HEK293, His-Avi) Q8NHL6 (G24-H458) ≥95%

Related Diseases

Diseases Alias
Human Cytomegalovirus Infection

Cytomegalovirus Infection

Cytomegalovirus Infections
Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria
Bare Lymphocyte Syndrome, Type I

Hla Class I Deficiency

Mhc Class I Deficiency

Bls, Type I

Bare Lymphocyte Syndrome Type I

Bare Lymphocyte Syndrome, Type I, Due To Tap2 Deficiency

Blsi

Mhc Class 1 Deficiency

Major Histocompatibility Complex Class 1 Deficiency

Bare Lymphocyte Syndrome 1

BLS1

Bls I

Bls Type I

Bl-1

Bare Lymphocyte Syndrome Type 1

Immunodeficiency By Defective Expression Of Hla - [Human Leukocyte Antigen] Class 1

Scid - [Severe Combined Immunodeficiency] Due To Absent Class 2 Hla Antigens

Bls - [Bare Lymphocyte Syndrome] Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07651 LILRB1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus LILRB1 MGD MGI:894311
Macaca fascicularis LILRB1 NCBI
Macaca mulatta LILRB1 NCBI