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  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. LILRB1 Antibody (YA1261)

LILRB1 Antibody (YA1261)

Cat. No.: HY-P81516
User Guide for Antibodies Technical Support

LILRB1 Antibody (YA1261) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LILRB1.

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사이즈 가격 재고 수량
20 μL 견적 받기 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
50 μL 견적 받기 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
100 μL 견적 받기 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
250 μL   견적 받기  
Synthetic products have potential research and development risk.
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • 제품 설명

제품 설명

LILRB1 Antibody (YA1261) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LILRB1.
Host

Rabbit
Clonality

Recombinant, Monoclonal
분자량
Predicted band size: 71 kDa;
Observed band size: 110 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human LILRB1
Application &
Dilution Ratio
Application Dilution Ratio
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:100-1:200
Sensitivity Endogenous Purity Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.292.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
선적

Shipping with blue ice.
Background
Function：Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:16455647, PubMed:28636952). Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11907092, PubMed:9285411, PubMed:9842885). Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (PubMed:16455647). Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells (PubMed:19304799, PubMed:29262349). Reprograms B cells toward an immune suppressive phenotype (PubMed:24453251)
Subcellular Localization：Cell membrane; Single-pass type I membrane protein; Secreted
Expression：
Tissue_specificity:Expression (protein level) in B cells, monocytes, and various dendritic cell (DC) subsets (including myeloid, plasmacytoid, and tolerant DCs) (PubMed:20448110, PubMed:24453251, PubMed:9285411, PubMed:9842885) . Expression (protein level) in decidual macrophages (PubMed:19304799) . Expression (protein level) in decidual NK cells (PubMed:29262349) .
Isoforms & Post-Translational Modification：Q8NHL6 has 5 isomers: Q8NHL6-1: 70819 Da (predicted); Q8NHL6-2: 70890 Da (predicted); Q8NHL6-3: 71019 Da (predicted); Q8NHL6-4: 70948 Da (predicted); Q8NHL6-5: 49356 Da (predicted).
Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6
Subunit：Binds PTPN6 when phosphorylated (PubMed:9285411). Binds FCER1A and FCGR1A (PubMed:11907092, PubMed:9842885). Interacts with human cytomegalovirus/HHV-5 protein UL18 (PubMed:10591185). Interacts with peptide-bound HLA-G-B2M complex (PubMed:16455647). Interacts with peptide-bound HLA-F-B2M complex but not with peptide-free HLA-F open conformer. It does not probe the peptide sequence directly (PubMed:28636952)
Database

Entrez Gene: 10859 Human

SwissProt: Q8NHL6 Human

OMIM: 604811 Human

Research Field

Immunology
Synonyms
LILRB1; ILT2; LIR1 ; MIR7; Leukocyte immunoglobulin-like receptor subfamily B member 1; LIR-1 ; Leukocyte immunoglobulin-like receptor 1; CD85j ; CD85 antigen-like family member J
각종 서류
User Guide for Antibodies (1077 KB)

LILRB1 Antibody (YA1261) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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상품명:
LILRB1 Antibody (YA1261)
Cat. No.:
HY-P81516
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