Pacsin1 - protein kinase C and casein kinase substrate in neurons 1 Gene

Also Known as H74; syndapin; mKIAA1379; A830061D09Rik

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 23969

Summary

Enables cytoskeletal protein binding activity; identical protein binding activity; and phospholipid binding activity. Involved in plasma membrane tubulation; protein localization to membrane; and synaptic vesicle endocytosis. Acts upstream of or within negative regulation of endocytosis. Located in COPI-coated vesicle and ruffle membrane. Is active in photoreceptor ribbon synapse and presynaptic endocytic zone. Is expressed in central nervous system; dorsal root ganglion; nasal cavity epithelium; and retina. Orthologous to human PACSIN1 (protein kinase C and Casein Kinase substrate in neurons 1). [provided by Alliance of Genome Resources, Apr 2022]

Pacsin1 Products (4)

mRNA Protein Name
NM_001286743.1 NP_001273672.1 protein kinase C and casein kinase substrate in neurons protein 1
NM_001286744.1 NP_001273673.1 protein kinase C and casein kinase substrate in neurons protein 1
NM_011861.3 NP_035991.1 protein kinase C and casein kinase substrate in neurons protein 1
NM_178365.4 NP_848142.1 protein kinase C and casein kinase substrate in neurons protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables cytoskeletal protein binding IDA
IDA: Inferred from direct assay
11082044 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
20404169 MGI
enables phospholipid binding IDA
IDA: Inferred from direct assay
20404169 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11082044 MGI
Biological Process GO Annotation Evidence 参考文献 由来
acts upstream of or within negative regulation of endocytosis IDA
IDA: Inferred from direct assay
11082044 MGI
involved in plasma membrane tubulation IMP
IMP: Inferred from mutant phenotype
20404169 MGI
involved in protein localization to membrane IMP
IMP: Inferred from mutant phenotype
21926968 MGI
involved in synaptic vesicle endocytosis IDA
IDA: Inferred from direct assay
21926968 MGI
involved in synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
21926968 MGI
Cellular Component GO Annotation Evidence 参考文献 由来
located in COPI-coated vesicle IDA
IDA: Inferred from direct assay
9746365 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
11082044 MGI
is active in photoreceptor ribbon synapse IDA
IDA: Inferred from direct assay
23785143 MGI
is active in presynaptic endocytic zone IDA
IDA: Inferred from direct assay
23785143 MGI
located in ruffle membrane IDA
IDA: Inferred from direct assay
20404169 MGI
NOT located in trans-Golgi network IDA
IDA: Inferred from direct assay
11082044 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein kinase C and casein kinase substrate in neurons protein 1

  • Syndapin I

  • syndapin-1

Pacsin1 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
Pacsin1 Q61644 Mapt Mus musculus P10637
IF
23035120
Intra
Pacsin1 Q61644 Pacsin1 Mus musculus Q61644
X-Ray Diffraction
20404169
Intra
Pacsin1 Q61644 DNM1 Homo sapiens Q05193
Pull Down
20404169
Intra
Pacsin1 Q61644 Mapt Mus musculus P10637
Pull Down
23035120
Intra
Pacsin1 Q61644 Dnm2 Mus musculus P39054
Anti Bait CoIP
21926968
Intra
Pacsin1 Q61644 Dnm3 Mus musculus Q8BZ98
Anti Bait CoIP
21926968
Intra
Pacsin1 Q61644 Dnm1 Mus musculus P39053
Anti Bait CoIP
21926968
Intra
Pacsin1 Q61644 Pacsin1 Mus musculus Q61644
Pull Down
20404169
Cross
Pacsin1 Q61644 Mapt Rattus norvegicus P19332-5
Anti Bait CoIP
23035120
Cross
Pacsin1 Q61644 Mapt Rattus norvegicus P19332-5
Pull Down
23035120
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS09957 PACSIN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19839 Pacsin1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26336 Pacsin1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Pacsin1 NCBI NCBI:29993