PACSIN1 - protein kinase C and casein kinase substrate in neurons 1 Gene

Also Known as SDPI

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29993

About PACSIN1

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:34,466,076-34,535,223 (from NCBI)

This gene has 7 transcripts (splice variants), 275 orthologues and 2 paralogues. Biased expression in brain (RPKM 42.1) and lymph node (RPKM 1.5).

Summary

Enables phospholipid binding activity. Involved in plasma membrane tubulation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PACSIN1 Products (2)

mRNA Protein Name
NM_001199583.3 NP_001186512.1 protein kinase C and casein kinase substrate in neurons protein 1
NM_020804.5 NP_065855.1 protein kinase C and casein kinase substrate in neurons protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables phospholipid binding IDA
IDA: Inferred from direct assay
19549836 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in plasma membrane tubulation IDA
IDA: Inferred from direct assay
19549836 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PACSIN1 Protein Structure

FCH

FCH: Fes/CIP4, and EFC/F-BAR homology domain (17 - 105)

SH3_9

SH3_9: Variant SH3 domain (392 - 442)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 444 a.a.
Protein Preferred Names Protein Names

protein kinase C and casein kinase substrate in neurons protein 1

  • syndapin I

PACSIN1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PACSIN1 Q9BY11 SLFN12 Homo sapiens Q8IYM2
Y2H Pooling
32814053
Intra
PACSIN1 Q9BY11 SLFN12 Homo sapiens Q8IYM2
Validated Y2H
32814053
Intra
PACSIN1 Q9BY11 SLFN12 Homo sapiens Q8IYM2
Y2H Array
32814053
Intra
PACSIN1 Q9BY11 COBLL1 Homo sapiens Q53SF7
Anti Tag CoIP
33961781
Intra
PACSIN1 Q9BY11 COBLL1 Homo sapiens Q53SF7
Y2H Pooling
20936779
Intra
PACSIN1 Q9BY11 COBL Homo sapiens O75128
Y2H Fragment Pooling
31413325
Intra
PACSIN1 Q9BY11 COBL Homo sapiens O75128
Anti Tag CoIP
33961781
Intra
PACSIN1 Q9BY11 FASLG Homo sapiens P48023
Anti Bait CoIP
16318909
Intra
PACSIN1 Q9BY11 FASLG Homo sapiens P48023
Anti Tag CoIP
16318909
Intra
PACSIN1 Q9BY11 FASLG Homo sapiens P48023
Pull Down
16318909
Intra
PACSIN1 Q9BY11 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
32296183
Intra
PACSIN1 Q9BY11 PACSIN2 Homo sapiens Q9UNF0
Anti Tag CoIP
33961781
Intra
PACSIN1 Q9BY11 PACSIN2 Homo sapiens Q9UNF0
Validated Y2H
25416956
Intra
PACSIN1 Q9BY11 PACSIN2 Homo sapiens Q9UNF0
Validated Y2H
32296183
Intra
PACSIN1 Q9BY11 PACSIN2 Homo sapiens Q9UNF0
Y2H Array
25416956
Intra
PACSIN1 Q9BY11 PACSIN2 Homo sapiens Q9UNF0
Y2H Pooling
20936779
Intra
PACSIN1 Q9BY11 PACSIN2 Homo sapiens Q9UNF0
Y2H Fragment Pooling
31413325
Intra
PACSIN1 Q9BY11 PACSIN2 Homo sapiens Q9UNF0
Y2H Prey Pooling
25416956
Intra
PACSIN1 Q9BY11 POT1 Homo sapiens Q9NUX5
Pull Down
21044950
Intra
PACSIN1 Q9BY11 PACSIN3 Homo sapiens Q9UKS6
Anti Tag CoIP
33961781
Intra
PACSIN1 Q9BY11 PACSIN3 Homo sapiens Q9UKS6
Anti Tag CoIP
28514442
Intra
PACSIN1 Q9BY11 PACSIN3 Homo sapiens Q9UKS6
Y2H Array
31515488
Intra
PACSIN1 Q9BY11 PACSIN3 Homo sapiens Q9UKS6
Y2H Prey Pooling
25416956
Intra
PACSIN1 Q9BY11 PACSIN3 Homo sapiens Q9UKS6
Validated Y2H
32296183
Intra
PACSIN1 Q9BY11 PACSIN3 Homo sapiens Q9UKS6
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PACSIN1 Proteins

Cat. No. Product Name Accession Purity
HY-P71183 PACSIN1 Protein, Human (HEK293, His) Q9BY11 (M1-I444) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09957 PACSIN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19839 Pacsin1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26336 Pacsin1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PACSIN1 VGNC VGNC:44231
Rattus norvegicus PACSIN1 RGD RGD:3247
Felis catus PACSIN1 VGNC VGNC:68681
Macaca mulatta PACSIN1 VGNC VGNC:75744
Bos taurus PACSIN1 VGNC VGNC:32542
Mus musculus PACSIN1 MGD MGI:1345181
Others PACSIN1 NCBI